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Lcmt1 Gene Detail
Summary
  • Symbol
    Lcmt1
  • Name
    leucine carboxyl methyltransferase 1
  • Synonyms
    Lcmt, LCMT-1, MGC:11807
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353593
    NCBI Gene: 30949
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:122977026-123029581 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 67.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1672 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353593
 protein coding gene Chr7:122969007-123029581 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032962
 protein coding gene Chr7:127514702-127574688 (+)
A/J MGP_AJ_G0032945
 protein coding gene Chr7:124210532-124262877 (+)
AKR/J MGP_AKRJ_G0032877
 protein coding gene Chr7:127369772-127421704 (+)
BALB/cJ MGP_BALBcJ_G0032950
 protein coding gene Chr7:123872618-123933493 (+)
C3H/HeJ MGP_C3HHeJ_G0032660
 protein coding gene Chr7:127270088-127331083 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033456
 protein coding gene Chr7:132480027-132551789 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030428
 protein coding gene Chr7:125506375-125559449 (+)
CAST/EiJ MGP_CASTEiJ_G0031988
 protein coding gene Chr7:119085859-119141382 (+)
CBA/J MGP_CBAJ_G0032633
 protein coding gene Chr7:136945225-137020396 (+)
DBA/2J MGP_DBA2J_G0032785
 protein coding gene Chr7:122183895-122244760 (+)
FVB/NJ MGP_FVBNJ_G0032738
 protein coding gene Chr7:122043038-122095452 (+)
LP/J MGP_LPJ_G0032879
 protein coding gene Chr7:128947010-129006184 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032770
 protein coding gene Chr7:138298683-138355460 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033476
 protein coding gene Chr7:126366442-126419254 (+)
PWK/PhJ MGP_PWKPhJ_G0031696
 protein coding gene Chr7:115137292-115189087 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031542
 protein coding gene Chr7:113141756-113203744 (+)
WSB/EiJ MGP_WSBEiJ_G0032101
 protein coding gene Chr7:127276022-127335831 (+)



Homology
more
  • Human Ortholog
    LCMT1, leucine carboxyl methyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LCMT1, leucine carboxyl methyltransferase 1
  • Synonyms
    CGI-68, LCMT, PPMT1
  • Links
    NCBI Gene ID: 51451
    neXtProt AC: NX_Q9UIC8
    UniProt: Q9UIC8

  • Chr Location
    16p12.1; chr16:25111731-25178231 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele are embryonic lethal. Mice homozygous for a hypomorphic gene trap allele exhibit partial embryonic lethality, insulin resistance and impaired glucose tolerance. Mice homozygous for a transgenic gene disruption exhibit kidney agenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    1
  • cDNA Data
    55
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30949 NCBI Gene Model | MGI Sequence Detail 52556 C57BL/6J ±  kb
    transcript NM_025304 RefSeq | MGI Sequence Detail 1369 Not Specified  
    polypeptide NP_079580 RefSeq | MGI Sequence Detail 332 Not Specified  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
      2.1.1.233
    • InterPro Domains
      IPR016651 Leucine carboxyl methyltransferase 1
      IPR007213 Methyltransferase Ppm1/Ppm2/Tcmp
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 55

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2142101
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 20
    • Earliest
      J:58971 De Baere I, et al., Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue. Biochemistry. 1999 Dec 14;38(50):16539-47
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory