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Fus Gene Detail
Summary
  • Symbol
    Fus
  • Name
    fused in sarcoma
  • Synonyms
    D430004D17Rik, D930039C12Rik, hnRNP P2, pigpen, Tls, translocated in liposarcoma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353633
    NCBI Gene: 233908
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127565276-127581204 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    332 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353633
 protein coding gene Chr7:127565276-127584873 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033067
 protein coding gene Chr7:132362303-132381815 (+)
A/J MGP_AJ_G0033050
 protein coding gene Chr7:128813723-128831663 (+)
AKR/J MGP_AKRJ_G0032982
 protein coding gene Chr7:132153319-132174658 (+)
BALB/cJ MGP_BALBcJ_G0033051
 protein coding gene Chr7:128472987-128491045 (+)
C3H/HeJ MGP_C3HHeJ_G0032765
 protein coding gene Chr7:132053460-132072208 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033560
 protein coding gene Chr7:137512033-137531041 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030533
 protein coding gene Chr7:130005701-130023157 (+)
CAST/EiJ MGP_CASTEiJ_G0032094
 protein coding gene Chr7:123845997-123865225 (+)
CBA/J MGP_CBAJ_G0032738
 protein coding gene Chr7:142185720-142206584 (+)
DBA/2J MGP_DBA2J_G0032890
 protein coding gene Chr7:126791022-126810688 (+)
FVB/NJ MGP_FVBNJ_G0032843
 protein coding gene Chr7:126652620-126671411 (+)
LP/J MGP_LPJ_G0032984
 protein coding gene Chr7:133824185-133842754 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032875
 protein coding gene Chr7:143260448-143279589 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033580
 protein coding gene Chr7:131136126-131157871 (+)
PWK/PhJ MGP_PWKPhJ_G0031801
 protein coding gene Chr7:119798376-119817092 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031647
 protein coding gene Chr7:117945551-117963677 (+)
WSB/EiJ MGP_WSBEiJ_G0032206
 protein coding gene Chr7:132102287-132121948 (+)



Homology
more
  • Human Ortholog
    FUS, FUS RNA binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FUS, FUS RNA binding protein
  • Synonyms
    ALS6, altFUS, ETM4, FUS1, HNRNPP2, POMP75, TLS
  • Links
    NCBI Gene ID: 2521
    neXtProt AC: NX_P35637
    UniProt: P35637

  • Chr Location
    16p11.2; chr16:31180110-31196963 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fus mouse models; 5 with human FUS associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 6 alleles in 8 genetic backgrounds
    12 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired lymphocyte development, chromosomal instability, increased cellular radiation sensitivity, high neonatal mortality, and male sterility associated with lack of chromosomal pairing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1011
  • Tissues
    255
  • cDNA Data
    172
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233908 NCBI Gene Model | MGI Sequence Detail 15929 C57BL/6J ±  kb
    transcript NM_139149 RefSeq | MGI Sequence Detail 1845 C57BL/6  
    polypeptide P56959 UniProt | EBI | MGI Sequence Detail 518 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 177
      cDNA 173
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2443475, MGI:2445182
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 21
      Diseases 1
      Gene Ontology 12
      Phenotypes 47
    • Earliest
      J:51309 Yang L, et al., Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. J Biol Chem. 1998 Oct 23;273(43):27761-4
    • Latest
      J:351972 Kodavati M, et al., FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease. Nat Commun. 2024 Mar 9;15(1):2156
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory