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Vps26a Gene Detail
Summary
  • Symbol
    Vps26a
  • Name
    VPS26 retromer complex component A
  • Synonyms
    HB58, H beta 58, Vps26
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353654
    NCBI Gene: 30930
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:62291014-62322584 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.41 cM, cytoband B3-B5
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    658 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353654
 protein coding gene Chr10:62290622-62322584 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017299
 protein coding gene Chr10:61885272-61918816 (-)
A/J MGP_AJ_G0017277
 protein coding gene Chr10:59991188-60023824 (-)
AKR/J MGP_AKRJ_G0017237
 protein coding gene Chr10:61555463-61588175 (-)
BALB/cJ MGP_BALBcJ_G0017237
 protein coding gene Chr10:60072583-60104815 (-)
C3H/HeJ MGP_C3HHeJ_G0017060
 protein coding gene Chr10:61476737-61509695 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017695
 protein coding gene Chr10:64102118-64136681 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015385
 protein coding gene Chr10:56958934-56990542 (-)
CAST/EiJ MGP_CASTEiJ_G0016631
 protein coding gene Chr10:61522732-61558669 (-)
CBA/J MGP_CBAJ_G0017032
 protein coding gene Chr10:66501220-66539341 (-)
DBA/2J MGP_DBA2J_G0017137
 protein coding gene Chr10:59264681-59297337 (-)
FVB/NJ MGP_FVBNJ_G0017131
 protein coding gene Chr10:58530548-58567453 (-)
LP/J MGP_LPJ_G0017211
 protein coding gene Chr10:62272005-62303799 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017159
 protein coding gene Chr10:68731177-68767132 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017733
 protein coding gene Chr10:61392942-61425894 (-)
PWK/PhJ MGP_PWKPhJ_G0016414
 protein coding gene Chr10:59129429-59161979 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016194
 protein coding gene Chr10:60702228-60795769 (-)
WSB/EiJ MGP_WSBEiJ_G0016695
 protein coding gene Chr10:61328561-61362528 (-)



Homology
more
  • Human Ortholog
    VPS26A, VPS26 retromer complex component A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS26A, VPS26 retromer complex component A
  • Synonyms
    HB58, Hbeta58, PEP8A, VPS26
  • Links
    NCBI Gene ID: 9559
    neXtProt AC: NX_O75436
    UniProt: O75436

  • Chr Location
    10q22.1; chr10:69123512-69174412 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human VPS26A associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from multigenic genotypes
    16 phenotype references
Homozygotes for a null mutation induced by transgene insertion exhibit retarded growth of the embryonic ectoderm beginning at embryonic day 7.5 and often, defects of the amnion and chorion. Mutant embryos arrest about day 9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    44
  • cDNA Data
    25
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020078 Ensembl Gene Model | MGI Sequence Detail 31571 C57BL/6J ±  kb
transcript ENSMUST00000092473 Ensembl | MGI Sequence Detail 2712 Not Applicable  
polypeptide ENSMUSP00000090130 Ensembl | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    Genomic 6
    cDNA 25
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2143458
References
more
  • Summaries
    All 53
    Developmental Gene Expression 7
    Gene Ontology 15
    Phenotypes 16
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:328738 Simoes S, et al., Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling. Cell Rep. 2021 Dec 28;37(13):110182
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory