Thop1 MGI Mouse Gene Detail - MGI:1354165

Symbol

Thop1
Name

thimet oligopeptidase 1
Synonyms

EP24.15

Feature Type

protein coding gene
IDs

MGI:1354165
NCBI Gene: 50492
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:80905917-80918194 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

3 experiments

SNPs within 2kb

406 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354165	protein coding gene	Chr10:80905869-80918393 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017534	protein coding gene	Chr10:81747664-81760188 (+)
A/J	MGP_AJ_G0017512	protein coding gene	Chr10:78865857-78878381 (+)
AKR/J	MGP_AKRJ_G0017473	protein coding gene	Chr10:81029723-81042245 (+)
BALB/cJ	MGP_BALBcJ_G0017474	protein coding gene	Chr10:79079763-79092284 (+)
C3H/HeJ	MGP_C3HHeJ_G0017297	protein coding gene	Chr10:81111988-81124511 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017928	protein coding gene	Chr10:84560014-84574123 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015617	protein coding gene	Chr10:75070239-75083128 (+)
CAST/EiJ	MGP_CASTEiJ_G0016864	protein coding gene	Chr10:81350994-81363477 (+)
CBA/J	MGP_CBAJ_G0017269	protein coding gene	Chr10:87850458-87862980 (+)
DBA/2J	MGP_DBA2J_G0017375	protein coding gene	Chr10:78059982-78072577 (+)
FVB/NJ	MGP_FVBNJ_G0017369	protein coding gene	Chr10:77302393-77314917 (+)
LP/J	MGP_LPJ_G0017446	protein coding gene	Chr10:82199066-82211588 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017395	protein coding gene	Chr10:89722686-89735213 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017969	protein coding gene	Chr10:81021429-81034335 (+)
PWK/PhJ	MGP_PWKPhJ_G0016645	protein coding gene	Chr10:77959418-77972504 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016435	protein coding gene	Chr10:79971404-79983949 (+)
WSB/EiJ	MGP_WSBEiJ_G0016924	protein coding gene	Chr10:81058790-81071323 (+)

Human Ortholog

THOP1, thimet oligopeptidase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

THOP1, thimet oligopeptidase 1
Synonyms

EP24.15, MEPD_HUMAN, MP78, TOP
Links

HGNC:11793

NCBI Gene ID: 7064

neXtProt AC: NX_P52888

UniProt: P52888
Chr Location

19p13.3; chr19:2785503-2815807 (+) GRCh38

MGI Vertebrate Homology

Thop1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: THOP1
Gene Tree

Thop1

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Phenotype Summary

23 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

12
Targeted

1
Genomic Mutations

1 involving Thop1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display thrombocytopenia and other hematopoietic cells anomalies, decreased susceptibility to sepsis, increased susceptibility to EAE, behavioral abnormalities, and altered neurotransmitter turnover.

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

2
cDNA Data

77
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase thop1

ZFIN thop1

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All Sequences

47
RefSeq

2
UniProt

3
CCDS

CCDS24042.1

Ensembl

ENSMUSG00000004929 (Evidence)
NCBI Gene

50492

			Length	Strain/Species	Flank
genomic	50492	NCBI Gene Model \| MGI Sequence Detail	12278	C57BL/6J	± kb
transcript	NM_022653	RefSeq \| MGI Sequence Detail	2585	ZRU/MplStud
polypeptide	Q8C1A5	UniProt \| EBI \| MGI Sequence Detail	687	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016317 thimet oligopeptidase

(term hierarchy)
EC

3.4.24.15
InterPro Domains

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR024077 Neurolysin/Thimet oligopeptidase, domain 2

IPR024080 Neurolysin/Thimet oligopeptidase, N-terminal

IPR045090 Peptidase M3A/M3B

IPR001567 Peptidase M3A/M3B catalytic domain
GlyGen

Q8C1A5 1 site, 1 O-linked glycan (1 site)

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All nucleic 77

cDNA 77

Microarray probesets 4

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MGI:2143529, MGI:2143586

Summaries

All 43

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Thop1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94665	Chr10:80905871-80905880 (+)	-41 bp
Tssr94666	Chr10:80905896-80905955 (+)	9 bp
Tssr94667	Chr10:80905972-80905987 (+)	63 bp
Tssr94668	Chr10:80906069-80906080 (+)	158 bp
Tssr94669	Chr10:80911347-80911375 (+)	5,444 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24