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Ebi3 Gene Detail
Summary
  • Symbol
    Ebi3
  • Name
    Epstein-Barr virus induced gene 3
  • Synonyms
    EBI-3, IL-27
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354171
    NCBI Gene: 50498
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56259640-56264022 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    170 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354171
 protein coding gene Chr17:56259623-56264022 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023902
 protein coding gene Chr17:57575020-57579578 (+)
A/J MGP_AJ_G0023862
 protein coding gene Chr17:56021135-56025533 (+)
AKR/J MGP_AKRJ_G0023829
 protein coding gene Chr17:56699980-56704378 (+)
BALB/cJ MGP_BALBcJ_G0023863
 protein coding gene Chr17:55858081-55862479 (+)
C3H/HeJ MGP_C3HHeJ_G0023626
 protein coding gene Chr17:57414773-57419171 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024307
 protein coding gene Chr17:59858371-59862769 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021754
 protein coding gene Chr17:52541904-52546363 (+)
CAST/EiJ MGP_CASTEiJ_G0023109
 protein coding gene Chr17:57720712-57724959 (+)
CBA/J MGP_CBAJ_G0023603
 protein coding gene Chr17:62150894-62155292 (+)
DBA/2J MGP_DBA2J_G0023731
 protein coding gene Chr17:54758293-54762691 (+)
FVB/NJ MGP_FVBNJ_G0023697
 protein coding gene Chr17:54273573-54277921 (+)
LP/J MGP_LPJ_G0023811
 protein coding gene Chr17:58297750-58302081 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023724
 protein coding gene Chr17:61719580-61723770 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024352
 protein coding gene Chr17:57081156-57085505 (+)
PWK/PhJ MGP_PWKPhJ_G0022854
 protein coding gene Chr17:54100234-54104497 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022666
 protein coding gene Chr17:53844314-53848409 (+)
WSB/EiJ MGP_WSBEiJ_G0023173
 protein coding gene Chr17:57693587-57698644 (+)



Homology
more
  • Human Ortholog
    EBI3, Epstein-Barr virus induced 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EBI3, Epstein-Barr virus induced 3
  • Synonyms
    IL-27B, IL27B, IL35B
  • Links
    NCBI Gene ID: 10148
    neXtProt AC: NX_Q14213
    UniProt: Q14213

  • Chr Location
    19p13.3; chr19:4229523-4237528 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit significantly reduced numbers of invariant natural killer (NK) T cells, show impaired Th2 responses, are resistant to the induction of oxazolone-induced colitis, and display impaired early Th1 immunity against Leishmania parasitic infections.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    884
  • Tissues
    26
  • cDNA Data
    19
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003206 Ensembl Gene Model | MGI Sequence Detail 4383 C57BL/6J ±  kb
    transcript ENSMUST00000003274 Ensembl | MGI Sequence Detail 1154 Not Applicable  
    polypeptide ENSMUSP00000003274 Ensembl | MGI Sequence Detail 228 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 62
    • Earliest
      J:64475 Puttagunta R, et al., Comparative maps of human 19p13.3 and mouse chromosome 10 allow identification of sequences at evolutionary breakpoints. Genome Res. 2000 Sep;10(9):1369-80
    • Latest
      J:340010 Li S, et al., STING-induced regulatory B cells compromise NK function in cancer immunity. Nature. 2022 Oct;610(7931):373-380
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory