About   Help   FAQ
Lats2 Gene Detail
Summary
  • Symbol
    Lats2
  • Name
    large tumor suppressor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354386
    NCBI Gene: 50523
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr14:57927119-57983669 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 30.28 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1277 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354386
 protein coding gene Chr14:57927119-57995845 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021410
 protein coding gene Chr14:51846324-51973006 (-)
A/J MGP_AJ_G0021371
 protein coding gene Chr14:50809424-50928079 (-)
AKR/J MGP_AKRJ_G0021346
 protein coding gene Chr14:52597861-52720514 (-)
BALB/cJ MGP_BALBcJ_G0021374
 protein coding gene Chr14:50757926-50871263 (-)
C3H/HeJ MGP_C3HHeJ_G0021153
 protein coding gene Chr14:52242979-52369056 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021813
 protein coding gene Chr14:54397080-54526098 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019353
 protein coding gene Chr14:48887907-49005756 (-)
CAST/EiJ MGP_CASTEiJ_G0020671
 protein coding gene Chr14:48576152-48705262 (-)
CBA/J MGP_CBAJ_G0021120
 protein coding gene Chr14:56017068-56154496 (-)
DBA/2J MGP_DBA2J_G0021241
 protein coding gene Chr14:50483751-50598303 (-)
FVB/NJ MGP_FVBNJ_G0021222
 protein coding gene Chr14:49873584-49995580 (-)
LP/J MGP_LPJ_G0021316
 protein coding gene Chr14:52881852-53009037 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021250
 protein coding gene Chr14:55362088-55489545 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021837
 protein coding gene Chr14:51745856-51865747 (-)
PWK/PhJ MGP_PWKPhJ_G0020414
 protein coding gene Chr14:47025234-47143812 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020247
 protein coding gene Chr14:47815118-47939364 (-)
WSB/EiJ MGP_WSBEiJ_G0020723
 protein coding gene Chr14:52059035-52181382 (-)



Homology
more
  • Human Ortholog
    LATS2, large tumor suppressor kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LATS2, large tumor suppressor kinase 2
  • Synonyms
    KPM
  • Links
    NCBI Gene ID: 26524
    neXtProt AC: NX_Q9NRM7
    UniProt: Q9NRM7

  • Chr Location
    13q12.11; chr13:20973036-21061586 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 5 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    2 images
    78 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with decreased cell proliferation, chromosomal instability, atrial hyperplasia, ventricular hypoplasia, delayed embryonic development, an irregular kinked neural tube, and hemorrhages.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    117
  • cDNA Data
    74
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50523 NCBI Gene Model | MGI Sequence Detail 56551 C57BL/6J ±  kb
    transcript NM_015771 RefSeq | MGI Sequence Detail 5213 ZRU/MplStud  
    polypeptide Q7TSJ6 UniProt | EBI | MGI Sequence Detail 1042 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 74
      Primer pair 3

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:2145781, MGI:2145807, MGI:2443802
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 25
      Gene Ontology 16
      Phenotypes 78
    • Earliest
      J:60693 Yabuta N, et al., Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Genomics. 2000 Jan 15;63(2):263-70
    • Latest
      J:355644 Nie L, et al., Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation. Mol Cell. 2024 Sep 5;84(17):3336-3353.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory