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Spag6l Gene Detail
Summary
  • Symbol
    Spag6l
  • Name
    sperm associated antigen 6-like
  • Synonyms
    PF16, Spag6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354388
    NCBI Gene: 50525
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:16570880-16647177 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.39 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1920 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354388
 protein coding gene Chr16:16570880-16647320 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022560
 protein coding gene Chr16:13845401-13932156 (-)
A/J MGP_AJ_G0022521
 protein coding gene Chr16:13159999-13244812 (-)
AKR/J MGP_AKRJ_G0022498
 protein coding gene Chr16:13709861-13780637 (-)
BALB/cJ MGP_BALBcJ_G0022526
 protein coding gene Chr16:13317783-13391809 (-)
C3H/HeJ MGP_C3HHeJ_G0022293
 protein coding gene Chr16:13799079-13889265 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022975
 protein coding gene Chr16:14046690-14137439 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020495
 protein coding gene Chr16:13230443-13322923 (-)
CAST/EiJ MGP_CASTEiJ_G0021820
 protein coding gene Chr16:13734964-13823193 (-)
CBA/J MGP_CBAJ_G0022262
 protein coding gene Chr16:14691447-14792936 (-)
DBA/2J MGP_DBA2J_G0022394
 protein coding gene Chr16:13103670-13183751 (-)
FVB/NJ MGP_FVBNJ_G0022369
 protein coding gene Chr16:13122854-13198448 (-)
LP/J MGP_LPJ_G0022461
 protein coding gene Chr16:13642916-13722368 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022391
 protein coding gene Chr16:14420367-14512740 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022988
 protein coding gene Chr16:13609650-13690674 (-)
PWK/PhJ MGP_PWKPhJ_G0021562
 protein coding gene Chr16:13344991-13424285 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021390
 protein coding gene Chr16:13627070-13700447 (-)
WSB/EiJ MGP_WSBEiJ_G0021868
 protein coding gene Chr16:13631871-13707330 (-)



Homology
more
  • Human Ortholog
    SPAG6, sperm associated antigen 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPAG6, sperm associated antigen 6
  • Synonyms
    CFAP194, CT141, FAP194, pf16, Repro-SA-1
  • Links
    NCBI Gene ID: 9576
    neXtProt AC: NX_O75602
    UniProt: O75602

  • Chr Location
    10p12.2; chr10:22345445-22454224 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Many homozygotes for a targeted null mutation exhibit reduced growth, hydrocephaly, and lethality by 8 weeks of age. Surviving males have sperm defects and are infertile, while females show reduced fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    17
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50525 NCBI Gene Model | MGI Sequence Detail 76298 C57BL/6J ±  kb
    transcript NM_015773 RefSeq | MGI Sequence Detail 2416 C57BL/6  
    polypeptide Q9JLI7 UniProt | EBI | MGI Sequence Detail 507 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 2
      cDNA 17
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 2
      Gene Ontology 17
      Phenotypes 17
    • Earliest
      J:60694 Sapiro R, et al., Sperm antigen 6 is the murine homologue of the Chlamydomonas reinhardtii central apparatus protein encoded by the PF16 locus. Biol Reprod. 2000 Mar;62(3):511-8
    • Latest
      J:322360 Li X, et al., Sperm-associated antigen 6 (Spag6) mutation leads to vestibular dysfunction in mice. J Pharmacol Sci. 2021 Dec;147(4):325-330
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory