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Fbxo8 Gene Detail
Summary
  • Symbol
    Fbxo8
  • Name
    F-box protein 8
  • Synonyms
    Fbx8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354696
    NCBI Gene: 50753
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:57004189-57046974 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 29.70 cM, cytoband B3.2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    970 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354696
 protein coding gene Chr8:57004125-57046974 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033620
 protein coding gene Chr8:56264318-56305753 (+)
A/J MGP_AJ_G0033602
 protein coding gene Chr8:53895149-53936043 (+)
AKR/J MGP_AKRJ_G0033527
 protein coding gene Chr8:55485904-55526333 (+)
BALB/cJ MGP_BALBcJ_G0033599
 protein coding gene Chr8:54205208-54245655 (+)
C3H/HeJ MGP_C3HHeJ_G0033308
 protein coding gene Chr8:56180412-56221317 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034115
 protein coding gene Chr8:58374470-58415873 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031063
 protein coding gene Chr8:49512829-49553663 (+)
CAST/EiJ MGP_CASTEiJ_G0032634
 protein coding gene Chr8:55534313-55575358 (+)
CBA/J MGP_CBAJ_G0033287
 protein coding gene Chr8:60465743-60507971 (+)
DBA/2J MGP_DBA2J_G0033440
 protein coding gene Chr8:53711041-53751858 (+)
FVB/NJ MGP_FVBNJ_G0033381
 protein coding gene Chr8:53078725-53119835 (+)
LP/J MGP_LPJ_G0033528
 protein coding gene Chr8:56270457-56311765 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033425
 protein coding gene Chr8:62034425-62078263 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034133
 protein coding gene Chr8:55727298-55768494 (+)
PWK/PhJ MGP_PWKPhJ_G0032342
 protein coding gene Chr8:53033497-53076293 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032178
 protein coding gene Chr8:54617751-54658784 (+)
WSB/EiJ MGP_WSBEiJ_G0032750
 protein coding gene Chr8:55951056-55995763 (+)



Homology
more
  • Human Ortholog
    FBXO8, F-box protein 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXO8, F-box protein 8
  • Synonyms
    DC10, FBS, FBX8
  • Links
    NCBI Gene ID: 26269
    neXtProt AC: NX_Q9NRD0
    UniProt: Q9NRD0

  • Chr Location
    4q34.1; chr4:174236658-174283667 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    8
  • cDNA Data
    66
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 50753 NCBI Gene Model | MGI Sequence Detail 42786 C57BL/6J ±  kb
transcript NM_001368347 RefSeq | MGI Sequence Detail 3623 C57BL/6  
polypeptide Q9QZN3 UniProt | EBI | MGI Sequence Detail 319 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 67
    cDNA 66
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory