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Fbxl6 Gene Detail
Summary
  • Symbol
    Fbxl6
  • Name
    F-box and leucine-rich repeat protein 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354705
    NCBI Gene: 30840
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:76419923-76422946 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 36.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354705
 protein coding gene Chr15:76419921-76422946 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021997
 protein coding gene Chr15:76614888-76617904 (-)
A/J MGP_AJ_G0021955
 protein coding gene Chr15:73825086-73828102 (-)
AKR/J MGP_AKRJ_G0021938
 protein coding gene Chr15:75825898-75828914 (-)
BALB/cJ MGP_BALBcJ_G0021964
 protein coding gene Chr15:73854335-73857351 (-)
C3H/HeJ MGP_C3HHeJ_G0021736
 protein coding gene Chr15:75873760-75876776 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022404
 protein coding gene Chr15:79482411-79485427 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019933
 protein coding gene Chr15:70488751-70491753 (-)
CAST/EiJ MGP_CASTEiJ_G0021255
 protein coding gene Chr15:76675921-76678938 (-)
CBA/J MGP_CBAJ_G0021703
 protein coding gene Chr15:81996080-81999096 (-)
DBA/2J MGP_DBA2J_G0021828
 protein coding gene Chr15:73362548-73365564 (-)
FVB/NJ MGP_FVBNJ_G0021808
 protein coding gene Chr15:72419361-72422377 (-)
LP/J MGP_LPJ_G0021899
 protein coding gene Chr15:76714503-76717519 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021833
 protein coding gene Chr15:87325312-87328334 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022424
 protein coding gene Chr15:76080328-76083350 (-)
PWK/PhJ MGP_PWKPhJ_G0020996
 protein coding gene Chr15:73528212-73531229 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020836
 protein coding gene Chr15:75798792-75801787 (-)
WSB/EiJ MGP_WSBEiJ_G0021307
 protein coding gene Chr15:76187220-76190233 (-)



Homology
more
  • Human Ortholog
    FBXL6, F-box and leucine rich repeat protein 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXL6, F-box and leucine rich repeat protein 6
  • Synonyms
    FBL6, FBL6A, PP14630
  • Links
    NCBI Gene ID: 26233
    neXtProt AC: NX_Q8N531
    UniProt: Q8N531

  • Chr Location
    8q24.3; chr8:144355431-144359376 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    71
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 30840 NCBI Gene Model | MGI Sequence Detail 3024 C57BL/6J ±  kb
transcript NM_013909 RefSeq | MGI Sequence Detail 1750 C57BL/6  
polypeptide Q9QXW0 UniProt | EBI | MGI Sequence Detail 535 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 71
    cDNA 71

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146138
References
more
  • Summaries
    All 50
    Diseases 1
    Gene Ontology 2
    Phenotypes 27
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:343190 Zhang J, et al., Elevated FBXL6 expression in hepatocytes activates VRK2-transketolase-ROS-mTOR-mediated immune evasion and liver cancer metastasis in mice. Exp Mol Med. 2023 Oct;55(10):2162-2176
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory