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Fbxo15 Gene Detail
Summary
  • Symbol
    Fbxo15
  • Name
    F-box protein 15
  • Synonyms
    ecat3, Fbx15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354755
    NCBI Gene: 50764
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:84952907-84999598 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 57.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1371 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354755
 protein coding gene Chr18:84952677-84999601 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024611
 protein coding gene Chr18:86104821-86155343 (+)
A/J MGP_AJ_G0024578
 protein coding gene Chr18:82333351-82379395 (+)
AKR/J MGP_AKRJ_G0024549
 protein coding gene Chr18:84783221-84830413 (+)
BALB/cJ MGP_BALBcJ_G0024576
 protein coding gene Chr18:82524877-82573718 (+)
C3H/HeJ MGP_C3HHeJ_G0024345
 protein coding gene Chr18:84888846-84941797 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025023
 protein coding gene Chr18:88260931-88310153 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022455
 protein coding gene Chr18:81036840-81066246 (+)
CAST/EiJ MGP_CASTEiJ_G0023818
 protein coding gene Chr18:85285106-85333690 (+)
CBA/J MGP_CBAJ_G0024315
 protein coding gene Chr18:91447287-91497589 (+)
DBA/2J MGP_DBA2J_G0024444
 protein coding gene Chr18:81850869-81898445 (+)
FVB/NJ MGP_FVBNJ_G0024411
 protein coding gene Chr18:81187307-81234191 (+)
LP/J MGP_LPJ_G0024529
 protein coding gene Chr18:85912434-85960027 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024441
 protein coding gene Chr18:92700644-92748174 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025072
 protein coding gene Chr18:85010237-85060406 (+)
PWK/PhJ MGP_PWKPhJ_G0023563
 protein coding gene Chr18:82267186-82315326 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023369
 protein coding gene Chr18:85026223-85072346 (+)
WSB/EiJ MGP_WSBEiJ_G0023880
 protein coding gene Chr18:84954233-85003828 (+)



Homology
more
  • Human Ortholog
    FBXO15, F-box protein 15
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXO15, F-box protein 15
  • Synonyms
    FBX15
  • Links
    NCBI Gene ID: 201456
    neXtProt AC: NX_Q8NCQ5
    UniProt: Q8NCQ5

  • Chr Location
    18q22.3; chr18:74073353-74147843 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Both male and female homozygous null mice develop normally and are fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    14
  • cDNA Data
    93
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034391 Ensembl Gene Model | MGI Sequence Detail 46692 C57BL/6J ±  kb
transcript ENSMUST00000223789 Ensembl | MGI Sequence Detail 1557 Not Applicable  
polypeptide ENSMUSP00000158102 Ensembl | MGI Sequence Detail 512 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 94
    cDNA 93
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2147307
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 2
    Phenotypes 14
  • Earliest
    J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
  • Latest
    J:246734 Donato V, et al., The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Nat Cell Biol. 2017 Apr;19(4):341-351
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory