Crim1 MGI Mouse Gene Detail - MGI:1354756 - cysteine rich transmembrane BMP regulator 1

Symbol

Crim1
Name

cysteine rich transmembrane BMP regulator 1

Feature Type

protein coding gene
IDs

MGI:1354756
NCBI Gene: 50766
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr17:78507677-78684021 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 48.09 cM
Mapping Data

2 experiments

SNPs within 2kb

5350 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354756	protein coding gene	Chr17:78507602-78684021 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024036	protein coding gene	Chr17:81010013-81193220 (+)
A/J	MGP_AJ_G0023993	protein coding gene	Chr17:78529429-78706429 (+)
AKR/J	MGP_AKRJ_G0023962	protein coding gene	Chr17:79719675-79900718 (+)
BALB/cJ	MGP_BALBcJ_G0023995	protein coding gene	Chr17:78387488-78564566 (+)
C3H/HeJ	MGP_C3HHeJ_G0023759	protein coding gene	Chr17:80615718-80798468 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024440	protein coding gene	Chr17:83956413-84145738 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021884	protein coding gene	Chr17:73924941-74104691 (+)
CAST/EiJ	MGP_CASTEiJ_G0023239	protein coding gene	Chr17:81201471-81381387 (+)
CBA/J	MGP_CBAJ_G0023733	protein coding gene	Chr17:87496677-87682757 (+)
DBA/2J	MGP_DBA2J_G0023862	protein coding gene	Chr17:77052465-77230662 (+)
FVB/NJ	MGP_FVBNJ_G0023828	protein coding gene	Chr17:76571204-76749622 (+)
LP/J	MGP_LPJ_G0023945	protein coding gene	Chr17:81860360-82041951 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023856	protein coding gene	Chr17:87612449-87795090 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024484	protein coding gene	Chr17:80177240-80360925 (+)
PWK/PhJ	MGP_PWKPhJ_G0022985	protein coding gene	Chr17:76527051-76706932 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022796	protein coding gene	Chr17:76963618-77146677 (+)
WSB/EiJ	MGP_WSBEiJ_G0023306	protein coding gene	Chr17:80994958-81175601 (+)

Human Ortholog

CRIM1, cysteine rich transmembrane BMP regulator 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRIM1, cysteine rich transmembrane BMP regulator 1
Synonyms

CRIM-1, S52
Links

HGNC:2359

NCBI Gene ID: 51232

neXtProt AC: NX_Q9NZV1

UniProt: Q9NZV1
Chr Location

2p22.2; chr2:36355778-36551135 (+) GRCh38

MGI Vertebrate Homology

Crim1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CRIM1
Gene Tree

Crim1

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Phenotype Summary

98 phenotypes from 5 alleles in 8 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

1
Endonuclease-mediated

3
Gene trapped

2
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations in this locus cause perinatal lethality, syndactyly, and eye and kidney abnormalities.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1049
Tissues

218
cDNA Data

57
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase crim1

ZFIN crim1

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All Sequences

63
RefSeq

10
UniProt

8
CCDS

CCDS28976.1

Ensembl

ENSMUSG00000024074 (Evidence)
NCBI Gene

50766

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024074	Ensembl Gene Model \| MGI Sequence Detail	176345	C57BL/6J	± kb
transcript	ENSMUST00000112498	Ensembl \| MGI Sequence Detail	5995	Not Applicable
polypeptide	ENSMUSP00000108117	Ensembl \| MGI Sequence Detail	1037	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000005871 cysteine-rich motor neuron 1 protein

(term hierarchy)
InterPro Domains

IPR004094 Antistasin-like domain

IPR052624 Cysteine-rich motor neuron 1

IPR045813 Cysteine-rich motor neuron 1 protein, C-terminal

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR011061 Hirudin/antistatin

IPR000867 Insulin-like growth factor-binding protein, IGFBP

IPR001007 VWFC domain
GlyGen

Q9JLL0 3 sites, 3 N-linked glycans (2 sites)

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All nucleic 70

cDNA 57

Primer pair 12

Other 1

Microarray probesets 4

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MGI:2146965

Summaries

All 75

Developmental Gene Expression 25

Gene Ontology 5

Phenotypes 26
Earliest

J:60432 Kolle G, et al., CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Mech Dev. 2000 Feb;90(2):181-93
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Crim1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145888	Chr17:78507619-78507657 (+)	-39 bp
Tssr145889	Chr17:78507669-78507687 (+)	1 bp
Tssr145890	Chr17:78507768-78507812 (+)	113 bp
Tssr145891	Chr17:78572257-78572262 (+)	64,583 bp
Tssr145892	Chr17:78579869-78579879 (+)	72,197 bp
Tssr145893	Chr17:78615902-78615909 (+)	108,229 bp
Tssr145894	Chr17:78683215-78683228 (+)	175,545 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24