Atp9b MGI Mouse Gene Detail - MGI:1354757 - ATPase, class II, type 9B

Symbol

Atp9b
Name

ATPase, class II, type 9B
Synonyms

IIb

Feature Type

protein coding gene
IDs

MGI:1354757
NCBI Gene: 50771
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr18:80777356-80977275 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 53.90 cM
Mapping Data

3 experiments

SNPs within 2kb

4182 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354757	protein coding gene	Chr18:80777356-80977291 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024598	protein coding gene	Chr18:81660221-81869587 (-)
A/J	MGP_AJ_G0024565	protein coding gene	Chr18:78091064-78289170 (-)
AKR/J	MGP_AKRJ_G0024536	protein coding gene	Chr18:80421493-80628340 (-)
BALB/cJ	MGP_BALBcJ_G0024563	protein coding gene	Chr18:78275703-78472588 (-)
C3H/HeJ	MGP_C3HHeJ_G0024332	protein coding gene	Chr18:80508317-80712571 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025010	protein coding gene	Chr18:83747523-83950580 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022441	protein coding gene	Chr18:76939094-77128544 (-)
CAST/EiJ	MGP_CASTEiJ_G0023805	protein coding gene	Chr18:80845681-81050511 (-)
CBA/J	MGP_CBAJ_G0024302	protein coding gene	Chr18:86794594-87014380 (-)
DBA/2J	MGP_DBA2J_G0024432	protein coding gene	Chr18:77641856-77839292 (-)
FVB/NJ	MGP_FVBNJ_G0024398	protein coding gene	Chr18:76955104-77150727 (-)
LP/J	MGP_LPJ_G0024516	protein coding gene	Chr18:81526452-81732566 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024428	protein coding gene	Chr18:88042983-88274636 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025059	protein coding gene	Chr18:80569709-80778666 (-)
PWK/PhJ	MGP_PWKPhJ_G0023550	protein coding gene	Chr18:78038535-78240716 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023356	protein coding gene	Chr18:80747279-80957426 (-)
WSB/EiJ	MGP_WSBEiJ_G0023867	protein coding gene	Chr18:80519087-80731649 (-)

Human Ortholog

ATP9B, ATPase phospholipid transporting 9B (putative)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATP9B, ATPase phospholipid transporting 9B (putative)
Synonyms

ATPASEP, ATPIIB, hMMR1, HUSSY-20, NEO1L
Links

HGNC:13541

NCBI Gene ID: 374868

neXtProt AC: NX_O43861

UniProt: O43861
Chr Location

18q23; chr18:79069285-79378287 (+) GRCh38

MGI Vertebrate Homology

Atp9b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATP9B
Gene Tree

Atp9b

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Gene trapped

3
Transposon induced

1
Genomic Mutations

1 involving Atp9b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available

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All GO Annotations

17
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

27
cDNA Data

12
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atp9b

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All Sequences

101
RefSeq

32
UniProt

8
CCDS

CCDS29370.1, CCDS89288.1

Ensembl

ENSMUSG00000024566 (Evidence)
NCBI Gene

50771

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024566	Ensembl Gene Model \| MGI Sequence Detail	199920	C57BL/6J	± kb
transcript	ENSMUST00000091790	Ensembl \| MGI Sequence Detail	5357	Not Applicable
polypeptide	ENSMUSP00000089394	Ensembl \| MGI Sequence Detail	1146	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000029295 probable phospholipid-transporting ATPase IIB

(term hierarchy)
EC

7.6.2.1
InterPro Domains

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR001757 P-type ATPase

IPR008250 P-type ATPase, A domain superfamily

IPR032630 P-type ATPase, C-terminal

IPR023299 P-type ATPase, cytoplasmic domain N

IPR044492 P-type ATPase, haloacid dehalogenase domain

IPR032631 P-type ATPase, N-terminal

IPR018303 P-type ATPase, phosphorylation site

IPR006539 P-type ATPase, subfamily IV

IPR023298 P-type ATPase, transmembrane domain superfamily
GlyGen

P98195 1 site, 1 N-linked glycan (1 site)

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All nucleic 16

Genomic 2

cDNA 14

Microarray probesets 6

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MGI:2147185

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 6
Earliest

J:59384 Halleck MS, et al., Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999 Nov 11;1(3):139-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Atp9b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154057	Chr18:80977269-80977292 (-)	-6 bp
Tssr154056	Chr18:80977188-80977260 (-)	51 bp
Tssr154055	Chr18:80944620-80944624 (-)	32,653 bp
Tssr154054	Chr18:80912900-80912904 (-)	64,373 bp
Tssr154053	Chr18:80904169-80904178 (-)	73,101 bp
Tssr154052	Chr18:80904151-80904167 (-)	73,116 bp
Tssr154051	Chr18:80904129-80904137 (-)	73,142 bp
Tssr154050	Chr18:80786264-80786276 (-)	191,005 bp
Tssr154049	Chr18:80786248-80786255 (-)	191,023 bp
Tssr154048	Chr18:80786225-80786241 (-)	191,042 bp
Tssr154047	Chr18:80786215-80786223 (-)	191,056 bp
Tssr154046	Chr18:80781516-80781526 (-)	195,754 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24