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Orc3 Gene Detail
Summary
  • Symbol
    Orc3
  • Name
    origin recognition complex, subunit 3
  • Synonyms
    Orc3l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354944
    NCBI Gene: 50793
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:34570796-34614944 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 16.81 cM, cytoband A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1246 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354944
 protein coding gene Chr4:34566781-34614944 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028127
 protein coding gene Chr4:32154750-32200249 (-)
A/J MGP_AJ_G0028085
 protein coding gene Chr4:30971660-31031611 (-)
AKR/J MGP_AKRJ_G0028048
 protein coding gene Chr4:31795935-31842508 (-)
BALB/cJ MGP_BALBcJ_G0028096
 protein coding gene Chr4:31261306-31308845 (-)
C3H/HeJ MGP_C3HHeJ_G0027825
 protein coding gene Chr4:32112934-32158941 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028538
 protein coding gene Chr4:33379769-33429263 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025879
 protein coding gene Chr4:29097684-29145379 (-)
CAST/EiJ MGP_CASTEiJ_G0027280
 protein coding gene Chr4:31904279-31951154 (-)
CBA/J MGP_CBAJ_G0027797
 protein coding gene Chr4:34453413-34517853 (-)
DBA/2J MGP_DBA2J_G0027941
 protein coding gene Chr4:30966972-31011348 (-)
FVB/NJ MGP_FVBNJ_G0027907
 protein coding gene Chr4:30382463-30426934 (-)
LP/J MGP_LPJ_G0028049
 protein coding gene Chr4:32240270-32289932 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027940
 protein coding gene Chr4:37060571-37109427 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028597
 protein coding gene Chr4:31823981-31870008 (-)
PWK/PhJ MGP_PWKPhJ_G0026999
 protein coding gene Chr4:30975970-31023246 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026828
 protein coding gene Chr4:31683026-31726675 (-)
WSB/EiJ MGP_WSBEiJ_G0027356
 protein coding gene Chr4:31824051-31867518 (-)



Homology
more
  • Human Ortholog
    ORC3, origin recognition complex subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ORC3, origin recognition complex subunit 3
  • Synonyms
    LAT, LATHEO, ORC3L
  • Links
    NCBI Gene ID: 23595
    neXtProt AC: NX_Q9UBD5
    UniProt: Q9UBD5

  • Chr Location
    6q15; chr6:87590067-87677823 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in the neural cells exhibit reduced neuronal precursor proliferation and reduced radial glial cell.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    15
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040044 Ensembl Gene Model | MGI Sequence Detail 44149 C57BL/6J ±  kb
transcript ENSMUST00000048706 Ensembl | MGI Sequence Detail 2300 Not Applicable  
polypeptide ENSMUSP00000048319 Ensembl | MGI Sequence Detail 715 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012032 origin recognition complex subunit 3
    (term hierarchy)
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR020795 Origin recognition complex, subunit 3
    IPR045663 Origin recognition complex subunit 3, insertion domain
    IPR045667 Origin recognition complex subunit 3, N-terminal
    IPR040855 Origin recognition complex subunit 3, winged helix C-terminal
Molecular
Reagents
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  • All nucleic 17
    Genomic 1
    cDNA 16

    Microarray probesets 7
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 10
    Phenotypes 12
  • Earliest
    J:60868 Springer J, et al., Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex. Cytogenet Cell Genet. 1999;87(3-4):245-51
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory