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Nt5c Gene Detail
Summary
  • Symbol
    Nt5c
  • Name
    5',3'-nucleotidase, cytosolic
  • Synonyms
    Dnt, Dnt1, Umph-2, Umph2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354954
    NCBI Gene: 50773
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115381251-115382659 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.84 cM, cytoband E
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354954
 protein coding gene Chr11:115381246-115382688 (-)
129S1/SvImJ ENSMUSG00200050620
 protein coding gene Chr11:112751978-112753420 (-)
A/J ENSMUSG00195025760
 protein coding gene Chr11:112453701-112455141 (-)
AKR/J ENSMUSG00220023632
 protein coding gene Chr11:112553355-112554797 (-)
BALB/cJ ENSMUSG00180050930
 protein coding gene Chr11:112756078-112757520 (-)
C3H/HeJ ENSMUSG00175031399
 protein coding gene Chr11:112705585-112707025 (-)
C57BL/6NJ ENSMUSG00215042162
 protein coding gene Chr11:112241134-112242576 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017406
 protein coding gene Chr11:111335989-111337437 (-)
CAST/EiJ ENSTCUG00005035184
 protein coding gene Chr11:112110610-112112052 (-)
CBA/J ENSMUSG00210049822
 protein coding gene Chr11:112425593-112427031 (-)
DBA/2J ENSMUSG00185025621
 protein coding gene Chr11:112747699-112749141 (-)
FVB/NJ ENSMUSG00205019913
 protein coding gene Chr11:112547221-112548659 (-)
JF1/MsJ ENSUMUG00000023562
 protein coding gene Chr11:113013140-113014574 (-)
LP/J ENSMUSG00230050826
 protein coding gene Chr11:113798960-113800400 (-)
NOD/ShiLtJ ENSMUSG00190043267
 protein coding gene Chr11:112776467-112777909 (-)
NZO/HlLtJ ENSMUSG00225049367
 protein coding gene Chr11:115854619-115856061 (-)
PWK/PhJ ENSLUMG00010022252
 protein coding gene Chr11:112528371-112529807 (-)
SPRET/EiJ ENSMSPG00010041197
 protein coding gene Chr11:113037823-113041119 (-)
WSB/EiJ ENSIUOG00005039844
 protein coding gene Chr11:112517364-112518808 (-)



Homology
more
  • Human Ortholog
    NT5C, 5', 3'-nucleotidase, cytosolic
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NT5C, 5', 3'-nucleotidase, cytosolic
  • Synonyms
    cdN, DNT, dNT-1, DNT1, HEL74, P5N2, PN-I, PN-II, UMPH2
  • Links
    NCBI Gene ID: 30833
    UniProt: Q8TCD5

  • Chr Location
    17q25.1; chr17:75130225-75131776 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    123
  • cDNA Data
    40
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 50773 NCBI Gene Model | MGI Sequence Detail 1409 C57BL/6J ±  kb
transcript NM_001417643 RefSeq | MGI Sequence Detail 849 C57BL/6  
polypeptide Q9JM14 UniProt | EBI | MGI Sequence Detail 200 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    Genomic 1
    cDNA 40

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15351, MGD-MRK-15353, MGI:98903
References
more
  • Summaries
    All 52
    Developmental Gene Expression 2
    Gene Ontology 12
    Phenotypes 9
  • Earliest
    J:7039 Swallow DM, et al., Isozymes of rodent 5'-nucleotidase: evidence for two independent structural loci Umph-1 and Umph-2. Ann Hum Genet. 1983 Jan;47 Pt 1:9-17
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory