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Copb2 Gene Detail
Summary
  • Symbol
    Copb2
  • Name
    COPI coat complex subunit beta 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354962
    NCBI Gene: 50797
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:98445784-98470428 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 51.40 cM, cytoband E3-F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    566 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354962
 protein coding gene Chr9:98445774-98470435 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035156
 protein coding gene Chr9:99868736-99894974 (+)
A/J MGP_AJ_G0035138
 protein coding gene Chr9:96363046-96388165 (+)
AKR/J MGP_AKRJ_G0035069
 protein coding gene Chr9:98728026-98752858 (+)
BALB/cJ MGP_BALBcJ_G0035130
 protein coding gene Chr9:96042922-96067584 (+)
C3H/HeJ MGP_C3HHeJ_G0034840
 protein coding gene Chr9:99108292-99132861 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035650
 protein coding gene Chr9:102733144-102757270 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032549
 protein coding gene Chr9:94125761-94150768 (+)
CAST/EiJ MGP_CASTEiJ_G0034151
 protein coding gene Chr9:98913310-98938476 (+)
CBA/J MGP_CBAJ_G0034808
 protein coding gene Chr9:106258150-106286494 (+)
DBA/2J MGP_DBA2J_G0034970
 protein coding gene Chr9:95869457-95892739 (+)
FVB/NJ MGP_FVBNJ_G0034918
 protein coding gene Chr9:94699996-94723076 (+)
LP/J MGP_LPJ_G0035049
 protein coding gene Chr9:100122798-100147002 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034957
 protein coding gene Chr9:108195313-108220044 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035672
 protein coding gene Chr9:98935813-98962191 (+)
PWK/PhJ MGP_PWKPhJ_G0033858
 protein coding gene Chr9:96081834-96106021 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033694
 protein coding gene Chr9:98996529-99021745 (+)
WSB/EiJ MGP_WSBEiJ_G0034271
 protein coding gene Chr9:98816899-98841549 (+)



Homology
more
  • Human Ortholog
    COPB2, COPI coat complex subunit beta 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COPB2, COPI coat complex subunit beta 2
  • Synonyms
    beta'-COP, MCPH19, OPDD
  • Links
    NCBI Gene ID: 9276
    neXtProt AC: NX_P35606
    UniProt: P35606

  • Chr Location
    3q23; chr3:139353946-139389736 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Copb2 mouse models; 1 with human COPB2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display early embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    858
  • Tissues
    26
  • cDNA Data
    272
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50797 NCBI Gene Model | MGI Sequence Detail 24645 C57BL/6J ±  kb
    transcript NM_015827 RefSeq | MGI Sequence Detail 3043 NOD  
    polypeptide O55029 UniProt | EBI | MGI Sequence Detail 905 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 274
      cDNA 273
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2143003
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:42235 Hosaka M, et al., Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). J Biochem. 1996 Oct;120(4):813-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory