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Dkkl1 Gene Detail
Summary
  • Symbol
    Dkkl1
  • Name
    dickkopf-like 1
  • Synonyms
    mSgy, SGY-1, SGY1, Soggy
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354963
    NCBI Gene: 50722
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44856943-44861571 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.19 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    211 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354963
 protein coding gene Chr7:44856943-44861592 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032209
 protein coding gene Chr7:45445298-45449656 (-)
A/J MGP_AJ_G0032188
 protein coding gene Chr7:44582403-44586762 (-)
AKR/J MGP_AKRJ_G0032124
 protein coding gene Chr7:45812716-45817074 (-)
BALB/cJ MGP_BALBcJ_G0032200
 protein coding gene Chr7:44582040-44586399 (-)
C3H/HeJ MGP_C3HHeJ_G0031916
 protein coding gene Chr7:46305630-46309988 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032692
 protein coding gene Chr7:47716249-47720607 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029706
 protein coding gene Chr7:47145049-47149289 (-)
CAST/EiJ MGP_CASTEiJ_G0031244
 protein coding gene Chr7:37699625-37703937 (-)
CBA/J MGP_CBAJ_G0031880
 protein coding gene Chr7:49284121-49288479 (-)
DBA/2J MGP_DBA2J_G0032038
 protein coding gene Chr7:44255080-44259439 (-)
FVB/NJ MGP_FVBNJ_G0031989
 protein coding gene Chr7:44031075-44035433 (-)
LP/J MGP_LPJ_G0032116
 protein coding gene Chr7:46130898-46135236 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032026
 protein coding gene Chr7:47993946-47998304 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032708
 protein coding gene Chr7:45031260-45035618 (-)
PWK/PhJ MGP_PWKPhJ_G0030967
 protein coding gene Chr7:37621006-37625400 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030804
 protein coding gene Chr7:33044945-33049385 (-)
WSB/EiJ MGP_WSBEiJ_G0031361
 protein coding gene Chr7:45524047-45528405 (-)



Homology
more
  • Human Ortholog
    DKKL1, dickkopf like acrosomal protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DKKL1, dickkopf like acrosomal protein 1
  • Synonyms
    CT34, SGY, SGY-1, SGY1
  • Links
    NCBI Gene ID: 27120
    neXtProt AC: NX_Q9UK85
    UniProt: Q9UK85

  • Chr Location
    19q13.33; chr19:49360515-49375116 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased sperm count associated with decreased spermatocyte apoptosis. Mice homozygous for a different knock-out allele exhibit decreased fertilization frequency in vitro and delayed fertilization in vivo.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    11
  • cDNA Data
    102
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030792 Ensembl Gene Model | MGI Sequence Detail 4629 C57BL/6J ±  kb
    transcript ENSMUST00000033057 Ensembl | MGI Sequence Detail 1149 Not Applicable  
    polypeptide ENSMUSP00000033057 Ensembl | MGI Sequence Detail 230 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 104
      cDNA 103
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2140257
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:58147 Krupnik VE, et al., Functional and structural diversity of the human Dickkopf gene family. Gene. 1999 Oct 1;238(2):301-13
    • Latest
      J:351297 Ge T, et al., Coiled-coil domain containing 159 is required for spermatid head and tail assembly in mice. Biol Reprod. 2024 May 9;110(5):877-894
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory