Nidd2n QTL Detail

Summary

• Symbol
  Nidd2n
• Name
  non-insulin-dependent diabetes mellitus 2 in NSY
• Synonyms
  Nidd2nsy

• Feature Type
  QTL
• IDs
  MGI:1355273
  NCBI Gene: 109526
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 14, 31.49 cM (cM position of peak correlated region/marker)
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  3 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  109526

References

• Summaries
  All 5

  Phenotypes 2
• Earliest
  J:55284 Ueda H, et al., Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait. Diabetes. 1999 May;48(5):1168-74
• Latest
  J:244901 Babaya N, et al., Genetic dissection of susceptibility genes for diabetes and related phenotypes on mouse chromosome 14 by means of congenic strains. BMC Genet. 2014 Aug 29;15:93

Candidate Genes for Nidd2n:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Smok1	Chr17, Syntenic	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 14, Smok1 (7.7 cM, formerly Tcr1) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTL Nidd2n (22.5 cM) maps near candidate gene Smok1.