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Il17rb Gene Detail
Summary
  • Symbol
    Il17rb
  • Name
    interleukin 17 receptor B
  • Synonyms
    Evi27, Il17br, IL-17ER, IL-17Rh1, IL17RH1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355292
    NCBI Gene: 50905
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:29718125-29730853 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 18.39 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    464 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355292
 protein coding gene Chr14:29718092-29730853 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021100
 protein coding gene Chr14:23100805-23113557 (-)
A/J MGP_AJ_G0021048
 protein coding gene Chr14:22229417-22242169 (-)
AKR/J MGP_AKRJ_G0021025
 protein coding gene Chr14:23322957-23335703 (-)
BALB/cJ MGP_BALBcJ_G0021052
 protein coding gene Chr14:22321970-22334722 (-)
C3H/HeJ MGP_C3HHeJ_G0020835
 protein coding gene Chr14:23183163-23195915 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021484
 protein coding gene Chr14:24019281-24032036 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019047
 protein coding gene Chr14:22300980-22313730 (-)
CAST/EiJ MGP_CASTEiJ_G0020360
 protein coding gene Chr14:22902382-22915173 (-)
CBA/J MGP_CBAJ_G0020802
 protein coding gene Chr14:24944981-24957733 (-)
DBA/2J MGP_DBA2J_G0020924
 protein coding gene Chr14:22273202-22285957 (-)
FVB/NJ MGP_FVBNJ_G0020908
 protein coding gene Chr14:22221462-22234214 (-)
LP/J MGP_LPJ_G0020993
 protein coding gene Chr14:23420384-23433138 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020934
 protein coding gene Chr14:24255764-24268514 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021517
 protein coding gene Chr14:23079108-23091857 (-)
PWK/PhJ MGP_PWKPhJ_G0020108
 protein coding gene Chr14:21698192-21711185 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019932
 protein coding gene Chr14:22641830-22654600 (-)
WSB/EiJ MGP_WSBEiJ_G0020415
 protein coding gene Chr14:23136767-23149562 (-)



Homology
more
  • Human Ortholog
    IL17RB, interleukin 17 receptor B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL17RB, interleukin 17 receptor B
  • Synonyms
    CRL4, EVI27, IL17BR, IL17RH1
  • Links
    NCBI Gene ID: 55540
    neXtProt AC: NX_Q9NRM6
    UniProt: Q9NRM6

  • Chr Location
    3p21.1; chr3:53846568-53865794 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 5 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice that are homozygous for a null allele have defects in their response to IL17A or IL17F. In addition this locus is a common site of retoviral integration in BXH2 murine myeloid leukemias and occurred at a CpG island 6 kb upstream of the Il17rb gene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    3
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50905 NCBI Gene Model | MGI Sequence Detail 12729 C57BL/6J ±  kb
    transcript NM_019583 RefSeq | MGI Sequence Detail 2061 ZRU/MplStud  
    polypeptide Q9JIP3 UniProt | EBI | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000008982 interleukin-17 receptor B
      (term hierarchy)
    • PDB
      3VBC
    • InterPro Domains
      IPR038683 Interleukin-17 receptor A/B, FnIII-like domain 1 superfamily
      IPR043046 Interleukin-17 receptor A/B, FnIII-like domain 2 superfamily
      IPR032356 Interleukin-17 receptor, fibronectin-III-like domain 1
      IPR039465 Interleukin-17 receptor-like
      IPR013568 SEFIR domain
    • GlyGen
      Q9JIP3 4 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 11

      Microarray probesets 3
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 38
    • Earliest
      J:58265 Li J, et al., Leukaemia disease genes: large-scale cloning and pathway predictions [see comments]. Nat Genet. 1999 Nov;23(3):348-53
    • Latest
      J:352224 Chandra V, et al., Gut epithelial Interleukin-17 receptor A signaling can modulate distant tumors growth through microbial regulation. Cancer Cell. 2024 Jan 8;42(1):85-100.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory