Hmgn5 MGI Mouse Gene Detail - MGI:1355295 - high-mobility group nucleosome binding domain 5

Symbol

Hmgn5
Name

high-mobility group nucleosome binding domain 5
Synonyms

GARP45, NBP-45, Nsbp1, nucleosome binding protein 45

Feature Type

protein coding gene
IDs

MGI:1355295
NCBI Gene: 50887
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

ChrX:108048143-108056986 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 47.92 cM
Mapping Data

2 experiments

SNPs within 2kb

163 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1355295	protein coding gene	ChrX:108048140-108057010 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036021	protein coding gene	ChrX:105854172-105862489 (-)
A/J	MGP_AJ_G0036000	protein coding gene	ChrX:105712004-105721368 (-)
AKR/J	MGP_AKRJ_G0035919	protein coding gene	ChrX:109004268-109013736 (-)
BALB/cJ	MGP_BALBcJ_G0035991	protein coding gene	ChrX:104397408-104406171 (-)
C3H/HeJ	MGP_C3HHeJ_G0035697	protein coding gene	ChrX:106305502-106314341 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036517	protein coding gene	ChrX:108901899-108910733 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033345	protein coding gene	ChrX:102778045-102786488 (-)
CAST/EiJ	MGP_CASTEiJ_G0034984	protein coding gene	ChrX:90348136-90356894 (-)
CBA/J	MGP_CBAJ_G0035673	protein coding gene	ChrX:112316765-112328319 (-)
DBA/2J	MGP_DBA2J_G0035827	protein coding gene	ChrX:104873663-104882531 (-)
FVB/NJ	MGP_FVBNJ_G0035767	protein coding gene	ChrX:104263829-104273749 (-)
LP/J	MGP_LPJ_G0035919	protein coding gene	ChrX:106862453-106870756 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035798	protein coding gene	ChrX:117328884-117344471 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036544	protein coding gene	ChrX:105404767-105413611 (-)
PWK/PhJ	MGP_PWKPhJ_G0034680	protein coding gene	ChrX:87882046-87891106 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034509	protein coding gene	ChrX:91191728-91204612 (-)
WSB/EiJ	MGP_WSBEiJ_G0035122	protein coding gene	ChrX:104145606-104154351 (-)

Human Ortholog

HMGN5, high mobility group nucleosome binding domain 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HMGN5, high mobility group nucleosome binding domain 5
Synonyms

NBP-45, NSBP1
Links

HGNC:8013

NCBI Gene ID: 79366

neXtProt AC: NX_P82970

UniProt: P82970
Chr Location

Xq21.1; chrX:81113699-81201913 (-) GRCh38

MGI Vertebrate Homology

Hmgn5 stringent orthology
1 human;1 mouse;2 rat
HCOP

vertebrate homology predictions: HMGN5
Gene Tree

Hmgn5

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Phenotype Summary

14 phenotypes from 2 alleles in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

2
Targeted

3
Find Mice (IMSR)

3 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased prepulse inhibition, abnormal erythrocyte cell number, abnormal glucose tolerance, decreased granulocyte, increased CD8+ T cells, increased IgA, decreased IgE and abnormal respiration.

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All GO Annotations

14
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

772
Tissues

54
cDNA Data

48
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

1
CCDS

CCDS41101.1

Ensembl

ENSMUSG00000031245 (Evidence)
NCBI Gene

50887

			Length	Strain/Species	Flank
genomic	50887	NCBI Gene Model \| MGI Sequence Detail	8844	C57BL/6J	± kb
transcript	NM_016710	RefSeq \| MGI Sequence Detail	1911	C57BL/6
polypeptide	Q9JL35	UniProt \| EBI \| MGI Sequence Detail	406	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011440 nucleosome-binding protein 1

(term hierarchy)
InterPro Domains

IPR040164 High mobility group nucleosome-binding domain-containing protein 5

IPR000079 High mobility group protein HMGN

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All nucleic 51

cDNA 49

Primer pair 2

Microarray probesets 4

Summaries

All 39

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 8
Earliest

J:60860 Shirakawa H, et al., NBP-45, a novel nucleosomal binding protein with a tissue-specific and developmentally regulated expression. J Biol Chem. 2000 Mar 3;275(9):6368-74
Latest

J:219709 Furusawa T, et al., Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness. Nat Commun. 2015;6:6138

TSS for Hmgn5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164059	ChrX:108057096-108057107 (-)	-116 bp
Tssr164058	ChrX:108057079-108057090 (-)	-99 bp
Tssr164057	ChrX:108057066-108057077 (-)	-86 bp
Tssr164056	ChrX:108056995-108057004 (-)	-14 bp
Tssr164055	ChrX:108056978-108056994 (-)	0 bp
Tssr164054	ChrX:108056950-108056977 (-)	22 bp
Tssr164052	ChrX:108049318-108049329 (-)	7,662 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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