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Prkn Gene Detail
Summary
  • Symbol
    Prkn
  • Name
    parkin RBR E3 ubiquitin protein ligase
  • Synonyms
    Park2, Parkin, PRKN
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355296
    NCBI Gene: 50873
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:11059271-12282248 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 7.80 cM, cytoband A3.2-A3.3
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28747 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355296
 protein coding gene Chr17:11059227-12282257 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023142
 protein coding gene Chr17:8446192-9692979 (+)
A/J MGP_AJ_G0023110
 protein coding gene Chr17:8347826-9553239 (+)
AKR/J MGP_AKRJ_G0023074
 protein coding gene Chr17:8107678-9367040 (+)
BALB/cJ MGP_BALBcJ_G0023110
 protein coding gene Chr17:8127696-9325055 (+)
C3H/HeJ MGP_C3HHeJ_G0022873
 protein coding gene Chr17:8378633-9622459 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023553
 protein coding gene Chr17:8776965-10092350 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021055
 protein coding gene Chr17:4884990-6067955 (-)
CAST/EiJ MGP_CASTEiJ_G0022387
 protein coding gene Chr17:8415765-9674184 (+)
CBA/J MGP_CBAJ_G0022845
 protein coding gene Chr17:9113418-10453556 (+)
DBA/2J MGP_DBA2J_G0022978
 protein coding gene Chr17:7986258-9183620 (+)
FVB/NJ MGP_FVBNJ_G0022948
 protein coding gene Chr17:7935913-9128340 (+)
LP/J MGP_LPJ_G0023050
 protein coding gene Chr17:8241367-9517347 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022967
 protein coding gene Chr17:8777182-10090661 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023579
 protein coding gene Chr17:8396581-9638933 (+)
PWK/PhJ MGP_PWKPhJ_G0022135
 protein coding gene Chr17:7678479-8880334 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021965
 protein coding gene Chr17:7749104-9032689 (+)
WSB/EiJ MGP_WSBEiJ_G0022444
 protein coding gene Chr17:8707625-9966574 (+)



Homology
more
  • Human Ortholog
    PRKN, parkin RBR E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKN, parkin RBR E3 ubiquitin protein ligase
  • Synonyms
    AR-JP, LPRS2, PARK2, PDJ
  • Links
    NCBI Gene ID: 5071
    neXtProt AC: NX_O60260
    UniProt: O60260

  • Chr Location
    6q26; chr6:161347417-162727775 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Prkn mouse models; 4 with human PRKN associations

Human Disease Mouse Models
      
IDs
 View 9 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 7 alleles in 10 genetic backgrounds
    18 phenotypes from multigenic genotypes
    1 images
    297 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Dopamine and glutatamate transmission are impaired in some targeted null mice, resulting in decreased exploratory behavior. These mice show decreased body weight and temperature. Park2 is inactivated as part of a large deletion in the quaking mouse, a dysmyelinating mutant with a pronounced tremor.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    286
  • GO References
    36
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    906
  • Tissues
    128
  • cDNA Data
    9
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023826 Ensembl Gene Model | MGI Sequence Detail 1222978 C57BL/6J ±  kb
    transcript ENSMUST00000191124 Ensembl | MGI Sequence Detail 3202 Not Applicable  
    polypeptide ENSMUSP00000140587 Ensembl | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 5
      cDNA 10
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:6156522
    References
    more
    • Summaries
      All 421
      Developmental Gene Expression 15
      Diseases 6
      Gene Ontology 36
      Phenotypes 297
    • Earliest
      J:13141 SIDMAN RL, et al., MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science. 1964 Apr 17;144:309-11
    • Latest
      J:353518 Delgado-Angles A, et al., Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice. J Physiol Biochem. 2024 Feb;80(1):41-51
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory