Thim Gene Detail

Summary

• Symbol
  Thim
• Name
  thymoma insertional mutation
• Synonyms
  Tim-1

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:1355309
  NCBI Gene: 117216
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 2, cytoband F2-G
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from multigenic genotypes
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Transgenic
  1
• Find Mice (IMSR)
  0 strains or lines available

Aging heterozygous mice carrying a transgene insertional mutation exhibit exophthalmos, liver congestion, peripheral edema and respiratory distress and develop thymomas of epithelial cell origin at a very high penetrance, with tumor progression being more aggressive in females.

Sequences &
Gene Models

• NCBI Gene
  117216

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:59903 Nakajima H, et al., Heritable lympho-epithelial thymoma resulting from a transgene insertional mutation. Oncogene. 2000 Jan 6;19(1):32-8
• Latest
  J:147011 Nakae S, et al., TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells. Blood. 2007 Oct 1;110(7):2565-8