Exosc9 MGI Mouse Gene Detail - MGI:1355319

Symbol

Exosc9
Name

exosome component 9
Synonyms

p5, p6, Pmscl1, PM/Scl-75, RRP45

Feature Type

protein coding gene
IDs

MGI:1355319
NCBI Gene: 50911
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr3:36606755-36619876 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 17.60 cM
Mapping Data

2 experiments

SNPs within 2kb

420 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1355319	protein coding gene	Chr3:36606755-36619876 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027160	protein coding gene	Chr3:34356029-34369047 (+)
A/J	MGP_AJ_G0027120	protein coding gene	Chr3:33700614-33713622 (+)
AKR/J	MGP_AKRJ_G0027089	protein coding gene	Chr3:34321718-34334737 (+)
BALB/cJ	MGP_BALBcJ_G0027132	protein coding gene	Chr3:33457196-33470317 (+)
C3H/HeJ	MGP_C3HHeJ_G0026875	protein coding gene	Chr3:34381247-34394255 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027578	protein coding gene	Chr3:36001375-36014496 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024939	protein coding gene	Chr3:31397543-31412675 (+)
CAST/EiJ	MGP_CASTEiJ_G0026328	protein coding gene	Chr3:34230047-34243069 (+)
CBA/J	MGP_CBAJ_G0026852	protein coding gene	Chr3:36981007-36993999 (+)
DBA/2J	MGP_DBA2J_G0026986	protein coding gene	Chr3:33154473-33167487 (+)
FVB/NJ	MGP_FVBNJ_G0026954	protein coding gene	Chr3:32605420-32618541 (+)
LP/J	MGP_LPJ_G0027098	protein coding gene	Chr3:35138933-35152064 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026974	protein coding gene	Chr3:39395519-39408517 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027637	protein coding gene	Chr3:34157848-34170842 (+)
PWK/PhJ	MGP_PWKPhJ_G0026061	protein coding gene	Chr3:32801995-32815107 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025873	protein coding gene	Chr3:33537092-33550136 (+)
WSB/EiJ	MGP_WSBEiJ_G0026402	protein coding gene	Chr3:34183554-34196548 (+)

Human Ortholog

EXOSC9, exosome component 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EXOSC9, exosome component 9
Synonyms

p5, p6, PCH1D, PMSCL1, PM/Scl-75, RRP45, Rrp45p
Links

HGNC:9137

NCBI Gene ID: 5393

neXtProt AC: NX_Q06265

UniProt: Q06265
Chr Location

4q27; chr4:121801318-121817021 (+) GRCh38

MGI Vertebrate Homology

Exosc9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EXOSC9
Gene Tree

Exosc9

Diseases

1 with human EXOSC9 associations

				Human Disease	Mouse Models
				pontocerebellar hypoplasia type 1D IDs pontocerebellar hypoplasia type 1D DOID:0112323 OMIM:618065

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

15 phenotype references

All Mutations and Alleles

17
Gene trapped

11
Radiation induced

2
Targeted

4
Genomic Mutations

2 involving Exosc9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available

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All GO Annotations

49
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

18
cDNA Data

13
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase exosc9

ZFIN exosc9

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All Sequences

53
RefSeq

2
UniProt

6
CCDS

CCDS17312.1

Ensembl

ENSMUSG00000027714 (Evidence)
NCBI Gene

50911

			Length	Strain/Species	Flank
genomic	50911	NCBI Gene Model \| MGI Sequence Detail	13122	C57BL/6J	± kb
transcript	NM_019393	RefSeq \| MGI Sequence Detail	1622	C57BL/6
polypeptide	Q9JHI7	UniProt \| EBI \| MGI Sequence Detail	438	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007266 exosome complex component RRP45

(term hierarchy)
InterPro Domains

IPR036345 Exoribonuclease, PH domain 2 superfamily

IPR001247 Exoribonuclease, phosphorolytic domain 1

IPR015847 Exoribonuclease, phosphorolytic domain 2

IPR050590 Exosome complex component Rrp42 subfamily

IPR033100 Exosome complex component RRP45

IPR027408 PNPase/RNase PH domain superfamily

IPR020568 Ribosomal protein uS5 domain 2-type superfamily

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All nucleic 16

cDNA 14

Primer pair 2

Microarray probesets 2

Summaries

All 48

Developmental Gene Expression 4

Diseases 1

Gene Ontology 9

Phenotypes 15
Earliest

J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Exosc9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28873	Chr3:36606749-36606826 (+)	33 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24