Chek2 MGI Mouse Gene Detail - MGI:1355321

Symbol

Chek2
Name

checkpoint kinase 2
Synonyms

CHK2, Rad53

Feature Type

protein coding gene
IDs

MGI:1355321
NCBI Gene: 50883
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr5:110987845-111022011 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 53.73 cM, cytoband F
Mapping Data

1 experiment

SNPs within 2kb

1023 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1355321	protein coding gene	Chr5:110987668-111022011 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029895	protein coding gene	Chr5:113322227-113354313 (+)
A/J	MGP_AJ_G0029861	protein coding gene	Chr5:108930840-108968504 (+)
AKR/J	MGP_AKRJ_G0029799	protein coding gene	Chr5:112389573-112426255 (+)
BALB/cJ	MGP_BALBcJ_G0029872	protein coding gene	Chr5:110303316-110338985 (+)
C3H/HeJ	MGP_C3HHeJ_G0029592	protein coding gene	Chr5:112831893-112869861 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030325	protein coding gene	Chr5:117775789-117813575 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027554	protein coding gene	Chr5:103765401-103800398 (+)
CAST/EiJ	MGP_CASTEiJ_G0029000	protein coding gene	Chr5:111693823-111728962 (+)
CBA/J	MGP_CBAJ_G0029559	protein coding gene	Chr5:122205720-122243106 (+)
DBA/2J	MGP_DBA2J_G0029709	protein coding gene	Chr5:109008241-109043203 (+)
FVB/NJ	MGP_FVBNJ_G0029666	protein coding gene	Chr5:107679577-107715116 (+)
LP/J	MGP_LPJ_G0029797	protein coding gene	Chr5:113874543-113905294 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029697	protein coding gene	Chr5:126848595-126883148 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030366	protein coding gene	Chr5:111832970-111863066 (+)
PWK/PhJ	MGP_PWKPhJ_G0028714	protein coding gene	Chr5:107590605-107626658 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028552	protein coding gene	Chr5:109300019-109344372 (+)
WSB/EiJ	MGP_WSBEiJ_G0029076	protein coding gene	Chr5:112310480-112347394 (+)

Human Ortholog

CHEK2, checkpoint kinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHEK2, checkpoint kinase 2
Synonyms

CDS1, CHK2, hCds1, HuCds1, LFS2, PP1425, RAD53, TPDS4
Links

HGNC:16627

NCBI Gene ID: 11200

neXtProt AC: NX_O96017

UniProt: O96017
Chr Location

22q12.1; chr22:28687743-28742422 (-) GRCh38

MGI Vertebrate Homology

Chek2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CHEK2
Gene Tree

Chek2

Diseases

8 with human CHEK2 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				female breast cancer IDs female breast cancer DOID:0050671
				Li-Fraumeni syndrome 2 IDs Li-Fraumeni syndrome 2 DOID:0111504 MESH:C563755 OMIM:609265
				male breast cancer IDs male breast cancer DOID:1614 DOID:9796 ICD9CM:175.9 MESH:D018567 UMLS_CUI:C0242788
				osteosarcoma IDs osteosarcoma DOID:3347 DOID:183 MESH:D012516 MESH:D018213 NCI:C9145 OMIM:259500 ORDO:668 UMLS_CUI:C0029463 UMLS_CUI:C0206639
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 3 alleles in 4 genetic backgrounds
31 phenotypes from multigenic genotypes
71 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

18
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Chek2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

54 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene does not increase tumor incidence. Cells from the thymus, central nervous system (CNS), hair follicles, and skin are resistant to ionizing radiation- and gamma irradiation-induced apoptosis.

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All GO Annotations

71
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

797
Tissues

33
cDNA Data

28
Literature Summary

27

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase chek2

ZFIN chek2

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All Sequences

64
RefSeq

22
UniProt

5
CCDS

CCDS19533.1

Ensembl

ENSMUSG00000029521 (Evidence)
NCBI Gene

50883

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029521	Ensembl Gene Model \| MGI Sequence Detail	34167	C57BL/6J	± kb
transcript	ENSMUST00000066160	Ensembl \| MGI Sequence Detail	2276	Not Applicable
polypeptide	ENSMUSP00000066679	Ensembl \| MGI Sequence Detail	546	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005418 serine/threonine-protein kinase Chk2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000253 Forkhead-associated (FHA) domain

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR008984 SMAD/FHA domain superfamily

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All nucleic 31

cDNA 28

Primer pair 3

Microarray probesets 3

Summaries

All 141

Developmental Gene Expression 27

Gene Ontology 14

Phenotypes 71
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:348825 Bai L, et al., BRCA1 safeguards genome integrity by activating chromosome asynapsis checkpoint to eliminate recombination-defective oocytes. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2401386121

TSS for Chek2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47910	Chr5:110987839-110987888 (+)	19 bp
Tssr47911	Chr5:110988097-110988149 (+)	278 bp
Tssr47912	Chr5:111015752-111015780 (+)	27,921 bp
Tssr1588	Chr5:111015796-111015804 (+)	27,955 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24