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Nasp Gene Detail
Summary
  • Symbol
    Nasp
  • Name
    nuclear autoantigenic sperm protein (histone-binding)
  • Synonyms
    5033430J04Rik, D4Ertd767e, Epcs32, Nasp-T
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355328
    NCBI Gene: 50927
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:116458249-116485138 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.24 cM, cytoband D1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    556 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355328
 protein coding gene Chr4:116458249-116488894 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028629
 protein coding gene Chr4:117504955-117531557 (-)
A/J MGP_AJ_G0028590
 protein coding gene Chr4:112999927-113027862 (-)
AKR/J MGP_AKRJ_G0028540
 protein coding gene Chr4:115441322-115468533 (-)
BALB/cJ MGP_BALBcJ_G0028611
 protein coding gene Chr4:113625142-113652870 (-)
C3H/HeJ MGP_C3HHeJ_G0028325
 protein coding gene Chr4:117011736-117038344 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029052
 protein coding gene Chr4:122048257-122077185 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026336
 protein coding gene Chr4:107036065-107065776 (-)
CAST/EiJ MGP_CASTEiJ_G0027759
 protein coding gene Chr4:114238826-114268708 (-)
CBA/J MGP_CBAJ_G0028292
 protein coding gene Chr4:125356553-125383142 (-)
DBA/2J MGP_DBA2J_G0028440
 protein coding gene Chr4:113630436-113657036 (-)
FVB/NJ MGP_FVBNJ_G0028408
 protein coding gene Chr4:112131678-112158254 (-)
LP/J MGP_LPJ_G0028542
 protein coding gene Chr4:117711056-117739467 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028435
 protein coding gene Chr4:130347845-130377703 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029089
 protein coding gene Chr4:116588233-116615644 (-)
PWK/PhJ MGP_PWKPhJ_G0027485
 protein coding gene Chr4:110408527-110436392 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027308
 protein coding gene Chr4:112863396-112890201 (-)
WSB/EiJ MGP_WSBEiJ_G0027838
 protein coding gene Chr4:116466705-116494366 (-)



Homology
more
  • Human Ortholog
    NASP, nuclear autoantigenic sperm protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NASP, nuclear autoantigenic sperm protein
  • Synonyms
    FLB7527, HMDRA1, PRO1999
  • Links
    NCBI Gene ID: 4678
    neXtProt AC: NX_P49321
    UniProt: P49321

  • Chr Location
    1p34.1; chr1:45583846-45618904 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality before implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    18
  • cDNA Data
    17
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028693 Ensembl Gene Model | MGI Sequence Detail 26890 C57BL/6J ±  kb
    transcript ENSMUST00000030456 Ensembl | MGI Sequence Detail 2520 Not Applicable  
    polypeptide ENSMUSP00000030456 Ensembl | MGI Sequence Detail 773 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000010993 nuclear autoantigenic sperm protein
      (term hierarchy)
    • InterPro Domains
      IPR051730 Nuclear Autoantigenic Sperm-associated Protein
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR019544 Tetratricopeptide, SHNi-TPR domain
    • GlyGen
      Q99MD9 3 sites, 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 18
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1289187, MGI:1914654, MGI:2140195, MGI:2145613
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:54434 Leimeister C, et al., Screen for genes regulated during early kidney morphogenesis. Dev Genet. 1999;24(3-4):273-83
    • Latest
      J:337597 Li J, et al., SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex. iScience. 2023 Jul 21;26(7):107042
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory