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Olig2 Gene Detail
Summary
  • Symbol
    Olig2
  • Name
    oligodendrocyte transcription factor 2
  • Synonyms
    Bhlhb1, bHLHe19, Olg-2, RK17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355331
    NCBI Gene: 50913
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:91022345-91025565 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 52.60 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355331
 protein coding gene Chr16:91016745-91025567 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023036
 protein coding gene Chr16:92224610-92227737 (+)
A/J MGP_AJ_G0023004
 protein coding gene Chr16:87917865-87920992 (+)
AKR/J MGP_AKRJ_G0022974
 protein coding gene Chr16:90563254-90566381 (+)
BALB/cJ MGP_BALBcJ_G0023006
 protein coding gene Chr16:88436448-88439575 (+)
C3H/HeJ MGP_C3HHeJ_G0022767
 protein coding gene Chr16:91131992-91135119 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023453
 protein coding gene Chr16:95210285-95213412 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020955
 protein coding gene Chr16:85625775-85628910 (+)
CAST/EiJ MGP_CASTEiJ_G0022286
 protein coding gene Chr16:91690677-91693815 (+)
CBA/J MGP_CBAJ_G0022736
 protein coding gene Chr16:99264341-99267480 (+)
DBA/2J MGP_DBA2J_G0022870
 protein coding gene Chr16:87819327-87822454 (+)
FVB/NJ MGP_FVBNJ_G0022844
 protein coding gene Chr16:86947269-86950396 (+)
LP/J MGP_LPJ_G0022940
 protein coding gene Chr16:91932737-91935864 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022865
 protein coding gene Chr16:103843312-103846439 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023471
 protein coding gene Chr16:91079161-91082288 (+)
PWK/PhJ MGP_PWKPhJ_G0022031
 protein coding gene Chr16:87993636-87996775 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021861
 protein coding gene Chr16:90635776-90638887 (+)
WSB/EiJ MGP_WSBEiJ_G0022338
 protein coding gene Chr16:91327888-91331015 (+)



Homology
more
  • Human Ortholog
    OLIG2, oligodendrocyte transcription factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OLIG2, oligodendrocyte transcription factor 2
  • Synonyms
    BHLHB1, bHLHe19, OLIGO2, PRKCBP2, RACK17
  • Links
    NCBI Gene ID: 10215
    neXtProt AC: NX_Q13516
    UniProt: Q13516

  • Chr Location
    21q22.11; chr21:33025935-33029196 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    3 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 5 genetic backgrounds
    70 phenotypes from multigenic genotypes
    294 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in neonatal lethality, impaired development of motoneurons and oligodendrocytes, aphagia, hypotonia, and abnormal posture and breathing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1714
  • Tissues
    374
  • cDNA Data
    16
  • Literature Summary
    665
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039830 Ensembl Gene Model | MGI Sequence Detail 3221 C57BL/6J ±  kb
    transcript ENSMUST00000035608 Ensembl | MGI Sequence Detail 2530 Not Applicable  
    polypeptide ENSMUSP00000036797 Ensembl | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011632 oligodendrocyte transcription factor 2
      (term hierarchy)
    • InterPro Domains
      IPR050359 Basic helix-loop-helix transcription factors
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR032658 Oligodendrocyte transcription factor 2, basic helix-loop-helix domain
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 20
      Primer pair 10
      Other 15

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146463
    References
    more
    • Summaries
      All 944
      Developmental Gene Expression 665
      Diseases 7
      Gene Ontology 18
      Phenotypes 294
    • Earliest
      J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
    • Latest
      J:358018 Zhang Y, et al., Astrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction. EMBO J. 2024 Nov;43(21):5114-5140
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory