Nckap1 MGI Mouse Gene Detail - MGI:1355333

Symbol

Nckap1
Name

NCK-associated protein 1
Synonyms

H19, Hem-2, Hem2, mh19, Nap1

Feature Type

protein coding gene
IDs

MGI:1355333
NCBI Gene: 50884
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr2:80330856-80411526 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 48.21 cM
Mapping Data

1 experiment

SNPs within 2kb

1796 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1355333	protein coding gene	Chr2:80330856-80411724 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025885	protein coding gene	Chr2:81083996-81168142 (-)
A/J	MGP_AJ_G0025862	protein coding gene	Chr2:77961309-78043909 (-)
AKR/J	MGP_AKRJ_G0025831	protein coding gene	Chr2:79996687-80080715 (-)
BALB/cJ	MGP_BALBcJ_G0025858	protein coding gene	Chr2:78087850-78172214 (-)
C3H/HeJ	MGP_C3HHeJ_G0025617	protein coding gene	Chr2:80233121-80318200 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026304	protein coding gene	Chr2:83470184-83558999 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023707	protein coding gene	Chr2:75171546-75252502 (-)
CAST/EiJ	MGP_CASTEiJ_G0025079	protein coding gene	Chr2:80671825-80758346 (-)
CBA/J	MGP_CBAJ_G0025598	protein coding gene	Chr2:86497611-86590186 (-)
DBA/2J	MGP_DBA2J_G0025729	protein coding gene	Chr2:77502945-77586953 (-)
FVB/NJ	MGP_FVBNJ_G0025691	protein coding gene	Chr2:76847887-76932704 (-)
LP/J	MGP_LPJ_G0025817	protein coding gene	Chr2:80942319-81031917 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025722	protein coding gene	Chr2:88356978-88472637 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026360	protein coding gene	Chr2:80161649-80246613 (-)
PWK/PhJ	MGP_PWKPhJ_G0024822	protein coding gene	Chr2:77444657-77529684 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024628	protein coding gene	Chr2:80413182-80496445 (-)
WSB/EiJ	MGP_WSBEiJ_G0025148	protein coding gene	Chr2:80801175-80898077 (-)

Human Ortholog

NCKAP1, NCK associated protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NCKAP1, NCK associated protein 1
Synonyms

HEM2, NAP1, NAP125, p125Nap1
Links

HGNC:7666

NCBI Gene ID: 10787

neXtProt AC: NX_Q9Y2A7

UniProt: Q9Y2A7
Chr Location

2q32.1; chr2:182909115-183038858 (-) GRCh38

MGI Vertebrate Homology

Nckap1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NCKAP1
Gene Tree

Nckap1

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Phenotype Summary

24 phenotypes from 4 alleles in 4 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

15
Targeted

4
Genomic Mutations

3 involving Nckap1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

72 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene exhibit growth arrest at midgestation, an open neural tube, cardia bifida, defective foregut development, defects in endoderm and mesoderm migration and sometimes duplication of the anteroposterior body axis.

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All GO Annotations

42
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

856
Tissues

73
cDNA Data

294
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nckap1

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All Sequences

65
RefSeq

8
UniProt

3
CCDS

CCDS16177.1, CCDS71082.1

Ensembl

ENSMUSG00000027002 (Evidence)
NCBI Gene

50884

			Length	Strain/Species	Flank
genomic	50884	NCBI Gene Model \| MGI Sequence Detail	80671	C57BL/6J	± kb
transcript	NM_001290745	RefSeq \| MGI Sequence Detail	4421	ZRU/MplStud
polypeptide	P28660	UniProt \| EBI \| MGI Sequence Detail	1128	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011035 Nck-associated protein 1

(term hierarchy)
InterPro Domains

IPR019137 Nck-associated protein 1
GlyGen

P28660 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 295

cDNA 294

Primer pair 1

Microarray probesets 3

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MGI:2139487

Summaries

All 56

Developmental Gene Expression 10

Gene Ontology 7

Phenotypes 18
Earliest

J:15086 Kato K, A collection of cDNA clones with specific expression patterns in mouse brain. Eur J Neurosci. 1990;2(8):704-11
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Nckap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr24950	Chr2:80411851-80411863 (-)	-331 bp
Tssr24949	Chr2:80411807-80411823 (-)	-289 bp
Tssr24948	Chr2:80411616-80411637 (-)	-101 bp
Tssr24947	Chr2:80411578-80411610 (-)	-68 bp
Tssr24946	Chr2:80411559-80411572 (-)	-40 bp
Tssr24945	Chr2:80411412-80411525 (-)	57 bp
Tssr24944	Chr2:80411339-80411364 (-)	174 bp
Tssr24943	Chr2:80411232-80411243 (-)	288 bp
Tssr24942	Chr2:80355065-80355082 (-)	56,452 bp
Tssr24941	Chr2:80355046-80355055 (-)	56,475 bp
Tssr24940	Chr2:80355036-80355041 (-)	56,487 bp
Tssr24939	Chr2:80355016-80355028 (-)	56,504 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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