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Tmod2 Gene Detail
Summary
  • Symbol
    Tmod2
  • Name
    tropomodulin 2
  • Synonyms
    neural tropomodulin, N-Tmod, NTMOD
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355335
    NCBI Gene: 50876
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:75472903-75518607 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 42.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1394 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355335
 protein coding gene Chr9:75472903-75518620 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035042
 protein coding gene Chr9:75893339-75939011 (-)
A/J MGP_AJ_G0035023
 protein coding gene Chr9:73237514-73284362 (-)
AKR/J MGP_AKRJ_G0034952
 protein coding gene Chr9:74986800-75034143 (-)
BALB/cJ MGP_BALBcJ_G0035015
 protein coding gene Chr9:72905769-72952005 (-)
C3H/HeJ MGP_C3HHeJ_G0034724
 protein coding gene Chr9:75453801-75501368 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035533
 protein coding gene Chr9:77906004-77951806 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032444
 protein coding gene Chr9:72591040-72637363 (-)
CAST/EiJ MGP_CASTEiJ_G0034046
 protein coding gene Chr9:75803672-75852070 (-)
CBA/J MGP_CBAJ_G0034696
 protein coding gene Chr9:80575426-80624257 (-)
DBA/2J MGP_DBA2J_G0034856
 protein coding gene Chr9:72905089-72951516 (-)
FVB/NJ MGP_FVBNJ_G0034798
 protein coding gene Chr9:72204125-72250172 (-)
LP/J MGP_LPJ_G0034937
 protein coding gene Chr9:76140903-76186597 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034839
 protein coding gene Chr9:81651434-81702368 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035556
 protein coding gene Chr9:75149504-75197932 (-)
PWK/PhJ MGP_PWKPhJ_G0033750
 protein coding gene Chr9:73193983-73240402 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033583
 protein coding gene Chr9:75387041-75434468 (-)
WSB/EiJ MGP_WSBEiJ_G0034158
 protein coding gene Chr9:75064475-75111804 (-)



Homology
more
  • Human Ortholog
    TMOD2, tropomodulin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMOD2, tropomodulin 2
  • Synonyms
    N-TMOD, NTMOD
  • Links
    NCBI Gene ID: 29767
    neXtProt AC: NX_Q9NZR1
    UniProt: Q9NZR1

  • Chr Location
    15q21.2; chr15:51751597-51816363 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in enhanced LTP, hyperactivity, impaired startle response, and impaired learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    55
  • cDNA Data
    13
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032186 Ensembl Gene Model | MGI Sequence Detail 45705 C57BL/6J ±  kb
    transcript ENSMUST00000098552 Ensembl | MGI Sequence Detail 9871 Not Applicable  
    polypeptide ENSMUSP00000096152 Ensembl | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 17
      Primer pair 2
      Other 2

      Microarray probesets 8
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:60558 Cox PR, et al., Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. Genomics. 2000 Jan 1;63(1):97-107
    • Latest
      J:350480 Mitra A, et al., Tmod2 Is a Regulator of Cocaine Responses through Control of Striatal and Cortical Excitability and Drug-Induced Plasticity. J Neurosci. 2024 May 1;44(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory