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Hpcal1 Gene Detail
Summary
  • Symbol
    Hpcal1
  • Name
    hippocalcin-like 1
  • Synonyms
    neural visinin-like 3, Nvp3, VILIP3, visinin like 3, Vnsl3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855689
    NCBI Gene: 53602
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:17740857-17841934 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 8.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3053 from dbSNP Build 142
  • Strain Annotations
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1855689
 protein coding gene Chr12:17740810-17841943 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0019558
 protein coding gene Chr12:15289866-15403816 (+)
BALB/cJ MGP_BALBcJ_G0019564
 protein coding gene Chr12:14847341-14952354 (+)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0019340
 protein coding gene Chr12:16633130-16639855 (+)
DBA/2J MGP_DBA2J_G0019453
 protein coding gene Chr12:14540022-14648073 (+)
FVB/NJ MGP_FVBNJ_G0019444
 protein coding gene Chr12:14411406-14500534 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0019479
 protein coding gene Chr12:16391954-16495990 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020051
 protein coding gene Chr12:14999308-15098316 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HPCAL1, hippocalcin like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HPCAL1, hippocalcin like 1
  • Synonyms
    BDR1, HLP2, VILIP-3
  • Links
    NCBI Gene ID: 3241
    neXtProt AC: NX_P37235
    UniProt: P37235

  • Chr Location
    2p25.1; chr2:10302889-10427617 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased susceptibility to diethylnitrosamine/CCl4-induced liver tumors with increased lipid biosynthesis in tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    15
  • cDNA Data
    5
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071379 Ensembl Gene Model | MGI Sequence Detail 101078 C57BL/6J ±  kb
    transcript ENSMUST00000071858 Ensembl | MGI Sequence Detail 1526 Not Applicable  
    polypeptide ENSMUSP00000071756 Ensembl | MGI Sequence Detail 193 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:331711 Chen T, et al., Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling. Theranostics. 2022;12(17):7450-7464
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory