Nap1l1 MGI Mouse Gene Detail - MGI:1855693 - nucleosome assembly protein 1-like 1

Symbol

Nap1l1
Name

nucleosome assembly protein 1-like 1
Synonyms

D10Ertd68e

Feature Type

protein coding gene
IDs

MGI:1855693
NCBI Gene: 53605
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:111309084-111334011 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 58.67 cM
Mapping Data

2 experiments

SNPs within 2kb

645 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1855693	protein coding gene	Chr10:111308754-111334011 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017721	protein coding gene	Chr10:113890133-113919558 (+)
A/J	MGP_AJ_G0017698	protein coding gene	Chr10:109561096-109586847 (+)
AKR/J	MGP_AKRJ_G0017660	protein coding gene	Chr10:112761896-112786735 (+)
BALB/cJ	MGP_BALBcJ_G0017662	protein coding gene	Chr10:109963003-109987586 (+)
C3H/HeJ	MGP_C3HHeJ_G0017487	protein coding gene	Chr10:112912440-112937819 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018119	protein coding gene	Chr10:117823939-117848878 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015798	protein coding gene	Chr10:104422719-104447986 (+)
CAST/EiJ	MGP_CASTEiJ_G0017048	protein coding gene	Chr10:113073312-113100271 (+)
CBA/J	MGP_CBAJ_G0017456	protein coding gene	Chr10:122455233-122480176 (+)
DBA/2J	MGP_DBA2J_G0017561	protein coding gene	Chr10:108697878-108721661 (+)
FVB/NJ	MGP_FVBNJ_G0017555	protein coding gene	Chr10:107684649-107712657 (+)
LP/J	MGP_LPJ_G0017635	protein coding gene	Chr10:114541582-114566785 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017584	protein coding gene	Chr10:125063007-125088990 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018157	protein coding gene	Chr10:112788779-112813555 (+)
PWK/PhJ	MGP_PWKPhJ_G0016830	protein coding gene	Chr10:108778330-108803731 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016620	protein coding gene	Chr10:111530186-111558717 (+)
WSB/EiJ	MGP_WSBEiJ_G0017108	protein coding gene	Chr10:112916952-112941817 (+)

Human Ortholog

NAP1L1, nucleosome assembly protein 1 like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NAP1L1, nucleosome assembly protein 1 like 1
Synonyms

NAP1, NAP1L, NRP
Links

HGNC:7637

NCBI Gene ID: 4673

neXtProt AC: NX_P55209

UniProt: P55209
Chr Location

12q21.2; chr12:76036585-76084735 (-) GRCh38

MGI Vertebrate Homology

Nap1l1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NAP1L1
Gene Tree

Nap1l1

Diseases

1 with human NAP1L1 associations

				Human Disease	Mouse Models
				pancreatic cancer IDs pancreatic cancer DOID:1793 DOID:14356 DOID:1797 DOID:3588 DOID:9859 ICD10CM:C25.0 ICD10CM:C25.1 ICD10CM:C25.2 ICD9CM:157.0 ICD9CM:157.1 ICD9CM:157.2 ICD9CM:157.8 KEGG:05212 MESH:D010190 NCI:C3305 ORDO:1333 ORDO:217074 UMLS_CUI:C0030297 UMLS_CUI:C0153458 UMLS_CUI:C0153459 UMLS_CUI:C0153460 UMLS_CUI:C0153463

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

100
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

93
Targeted

3
Genomic Mutations

1 involving Nap1l1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available

Mice homozygous for a homozygous mutation exhibit prenatal lethality and impaired neural progenitor cell proliferation and differentiation.

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All GO Annotations

17
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

46
cDNA Data

30
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nap1l1

ZFIN nap1l1

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All Sequences

100
RefSeq

21
UniProt

4
CCDS

CCDS36058.1, CCDS48690.1

Ensembl

ENSMUSG00000058799 (Evidence)
NCBI Gene

53605

			Length	Strain/Species	Flank
genomic	ENSMUSG00000058799	Ensembl Gene Model \| MGI Sequence Detail	24928	C57BL/6J	± kb
transcript	ENSMUST00000065917	Ensembl \| MGI Sequence Detail	1486	Not Applicable
polypeptide	ENSMUSP00000070068	Ensembl \| MGI Sequence Detail	391	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010975 nucleosome assembly protein 1-like 1

(term hierarchy)
InterPro Domains

IPR037231 NAP-like superfamily

IPR002164 Nucleosome assembly protein (NAP)
GlyGen

P28656 1 site, 1 O-linked glycan (1 site)

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All nucleic 33

cDNA 30

Primer pair 3

Microarray probesets 11

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MGI:1098627, MGI:2141803, MGI:2143550

Summaries

All 57

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:263406 Qiao H, et al., Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain. Cell Rep. 2018 Feb 27;22(9):2279-2293

TSS for Nap1l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95759	Chr10:111309047-111309062 (+)	-29 bp
Tssr95760	Chr10:111309081-111309103 (+)	8 bp
Tssr95761	Chr10:111309114-111309123 (+)	35 bp
Tssr3351	Chr10:111309127-111309128 (+)	44 bp
Tssr95762	Chr10:111309823-111309827 (+)	741 bp
Tssr95763	Chr10:111321208-111321219 (+)	12,130 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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