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Tslp Gene Detail
Summary
  • Symbol
    Tslp
  • Name
    thymic stromal lymphopoietin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855696
    NCBI Gene: 53603
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:32948436-32952850 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 18.12 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1855696
 protein coding gene Chr18:32948436-32952852 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024229
 protein coding gene Chr18:30981973-30986392 (+)
A/J MGP_AJ_G0024195
 protein coding gene Chr18:29943856-29948266 (+)
AKR/J MGP_AKRJ_G0024164
 protein coding gene Chr18:30773417-30777836 (+)
BALB/cJ MGP_BALBcJ_G0024195
 protein coding gene Chr18:30019182-30023583 (+)
C3H/HeJ MGP_C3HHeJ_G0023963
 protein coding gene Chr18:30824681-30829082 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024637
 protein coding gene Chr18:32088629-32093045 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022078
 protein coding gene Chr18:30152764-30157191 (+)
CAST/EiJ MGP_CASTEiJ_G0023438
 protein coding gene Chr18:30704067-30708481 (+)
CBA/J MGP_CBAJ_G0023931
 protein coding gene Chr18:33062378-33066788 (+)
DBA/2J MGP_DBA2J_G0024063
 protein coding gene Chr18:29622531-29626941 (+)
FVB/NJ MGP_FVBNJ_G0024029
 protein coding gene Chr18:29325067-29329486 (+)
LP/J MGP_LPJ_G0024144
 protein coding gene Chr18:31050401-31054818 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024057
 protein coding gene Chr18:34371823-34378923 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024685
 protein coding gene Chr18:30619419-30623838 (+)
PWK/PhJ MGP_PWKPhJ_G0023181
 protein coding gene Chr18:29774054-29778477 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022990
 protein coding gene Chr18:30885023-30889428 (+)
WSB/EiJ MGP_WSBEiJ_G0023501
 protein coding gene Chr18:30539721-30544101 (+)



Homology
more
  • Human Ortholog
    TSLP, thymic stromal lymphopoietin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSLP, thymic stromal lymphopoietin
  • Links
    NCBI Gene ID: 85480
    neXtProt AC: NX_Q969D9
    UniProt: Q969D9

  • Chr Location
    5q22.1; chr5:111070062-111078026 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Tslp mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    72 phenotypes from 8 alleles in 9 genetic backgrounds
    6 phenotypes from multigenic genotypes
    1 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit resistance to MC903-induced atopic dermatitis. Mice homozygous for another knock-out allele exhibit altered airway inflammation induced by LPS.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    14
  • cDNA Data
    8
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024379 Ensembl Gene Model | MGI Sequence Detail 4415 C57BL/6J ±  kb
    transcript ENSMUST00000025237 Ensembl | MGI Sequence Detail 1126 Not Applicable  
    polypeptide ENSMUSP00000025237 Ensembl | MGI Sequence Detail 140 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 8
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 14
      Diseases 3
      Gene Ontology 6
      Phenotypes 47
    • Earliest
      J:33087 Ray RJ, et al., Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro. Eur J Immunol. 1996 Jan;26(1):10-6
    • Latest
      J:355461 Deng Z, et al., Single-cell transcriptomics reveals the cellular identity of a novel progenitor population crucial for murine neural tube closure. Heliyon. 2024 Sep 15;10(17):e37259
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory