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Atp5f1e Gene Detail
Summary
  • Symbol
    Atp5f1e
  • Name
    ATP synthase F1 subunit epsilon
  • Synonyms
    2410043G19Rik, Atp5e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855697
    NCBI Gene: 67126
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:174302868-174305894 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 97.95 cM, cytoband H4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1855697
 protein coding gene Chr2:174302865-174305898 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026969
 protein coding gene Chr2:180821313-180824348 (-)
A/J MGP_AJ_G0026936
 protein coding gene Chr2:173200163-173203198 (-)
AKR/J MGP_AKRJ_G0026907
 protein coding gene Chr2:178415767-178418801 (-)
BALB/cJ MGP_BALBcJ_G0026945
 protein coding gene Chr2:173597203-173600237 (-)
C3H/HeJ MGP_C3HHeJ_G0026687
 protein coding gene Chr2:178795719-178798752 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027392
 protein coding gene Chr2:186013105-186016138 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024761
 protein coding gene Chr2:166435190-166438225 (-)
CAST/EiJ MGP_CASTEiJ_G0026146
 protein coding gene Chr2:179524639-179527677 (-)
CBA/J MGP_CBAJ_G0026664
 protein coding gene Chr2:192946608-192949642 (-)
DBA/2J MGP_DBA2J_G0026802
 protein coding gene Chr2:172298920-172301953 (-)
FVB/NJ MGP_FVBNJ_G0026768
 protein coding gene Chr2:170922702-170925720 (-)
LP/J MGP_LPJ_G0026903
 protein coding gene Chr2:180733223-180736258 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026787
 protein coding gene Chr2:195838034-195841058 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027449
 protein coding gene Chr2:178444833-178447866 (-)
PWK/PhJ MGP_PWKPhJ_G0025882
 protein coding gene Chr2:172113663-172116692 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025682
 protein coding gene Chr2:177491464-177495884 (-)
WSB/EiJ MGP_WSBEiJ_G0026218
 protein coding gene Chr2:179408920-179411953 (-)



Homology
more
  • Human Ortholog
    ATP5F1E, ATP synthase F1 subunit epsilon
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP5F1E, ATP synthase F1 subunit epsilon
  • Synonyms
    ATP5E, ATPE, MC5DN3
  • Links
    NCBI Gene ID: 514
    neXtProt AC: NX_P56381
    UniProt: P56381

  • Chr Location
    20q13.32; chr20:59025475-59032345 (-)  GRCh38
  • Human Ortholog
    ATP5F1EP2, ATP synthase F1 subunit epsilon pseudogene 2
  • Synonyms
    ATP5EP2
  • Links
    NCBI Gene ID: 432369
    UniProt: Q5VTU8

  • Chr Location
    13q12.2; chr13:27945206-27945573 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ATP5F1E associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    94
  • cDNA Data
    143
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67126 NCBI Gene Model | MGI Sequence Detail 3027 C57BL/6J ±  kb
transcript NM_025983 RefSeq | MGI Sequence Detail 419 C57BL/6  
polypeptide P56382 UniProt | EBI | MGI Sequence Detail 52 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004457 ATP synthase subunit epsilon, mitochondrial
    (term hierarchy)
  • InterPro Domains
    IPR006721 ATP synthase, F1 complex, epsilon subunit, mitochondrial
    IPR036742 ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial
  • GlyGen
    P56382 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 143
    cDNA 143

    Microarray probesets 3
Other
Accession IDs
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MGI:1914376, MGI:2139226, MGI:7469636
References
more
  • Summaries
    All 49
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 12
  • Earliest
    J:61560 Tu Q, et al., Cloning, characterization and mapping of the human ATP5E gene, identification of pseudogene ATP5EP1, and definition of the ATP5E motif. Biochem J. 2000 Apr 1;347 Pt 1:17-21
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory