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Oaz3 Gene Detail
Summary
  • Symbol
    Oaz3
  • Name
    ornithine decarboxylase antizyme 3
  • Synonyms
    antizyme 3, AZ-3, AZ3, Oaz-t, ornithine decarboxylase antizyme in testis
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858170
    NCBI Gene: 53814
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:94340694-94343958 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.66 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    146 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858170
 protein coding gene Chr3:94339721-94351222 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027550
 protein coding gene Chr3:95005756-95017161 (-)
A/J MGP_AJ_G0027509
 protein coding gene Chr3:92115993-92127436 (-)
AKR/J MGP_AKRJ_G0027477
 protein coding gene Chr3:94208544-94219940 (-)
BALB/cJ MGP_BALBcJ_G0027520
 protein coding gene Chr3:91818326-91829712 (-)
C3H/HeJ MGP_C3HHeJ_G0027256
 protein coding gene Chr3:94506219-94517654 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027969
 protein coding gene Chr3:98596407-98607788 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025311
 protein coding gene Chr3:88608967-88620600 (-)
CAST/EiJ MGP_CASTEiJ_G0026704
 protein coding gene Chr3:93848764-93863529 (-)
CBA/J MGP_CBAJ_G0027232
 protein coding gene Chr3:102089276-102100664 (-)
DBA/2J MGP_DBA2J_G0027371
 protein coding gene Chr3:91381479-91392850 (-)
FVB/NJ MGP_FVBNJ_G0027341
 protein coding gene Chr3:89480087-89491157 (-)
LP/J MGP_LPJ_G0027479
 protein coding gene Chr3:96314016-96326122 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027368
 protein coding gene Chr3:108321994-108334243 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028023
 protein coding gene Chr3:93888497-93899877 (-)
PWK/PhJ MGP_PWKPhJ_G0026432
 protein coding gene Chr3:91268361-91280696 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026253
 protein coding gene Chr3:92228119-92242296 (-)
WSB/EiJ MGP_WSBEiJ_G0026787
 protein coding gene Chr3:94236973-94249093 (-)



Homology
more
  • Human Ortholog
    OAZ3, ornithine decarboxylase antizyme 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OAZ3, ornithine decarboxylase antizyme 3
  • Synonyms
    AZ3, OAZ-t, TISP15
  • Links
    NCBI Gene ID: 51686
    neXtProt AC: NX_Q9UMX2
    UniProt: Q9UMX2

  • Chr Location
    1q21.3; chr1:151762899-151771334 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit male infertility due to detachment of sperm tail and head during sperm maturation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    7
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53814 NCBI Gene Model | MGI Sequence Detail 3265 C57BL/6J ±  kb
    transcript NM_016901 RefSeq | MGI Sequence Detail 955 C57BL/6  
    polypeptide Q9R109 UniProt | EBI | MGI Sequence Detail 243 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 12
      Phenotypes 6
    • Earliest
      J:61648 Tosaka Y, et al., Identification and characterization of testis specific ornithine decarboxylase antizyme (OAZ-t) gene: expression in haploid germ cells and polyamine-induced frameshifting. Genes Cells. 2000 Apr;5(4):265-76
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory