Mybph MGI Mouse Gene Detail - MGI:1858196

Symbol

Mybph
Name

myosin binding protein H

Feature Type

protein coding gene
IDs

MGI:1858196
NCBI Gene: 53311
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:134121186-134128970 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 58.15 cM
Mapping Data

2 experiments

SNPs within 2kb

233 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858196	protein coding gene	Chr1:134121159-134128975 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016500	protein coding gene	Chr1:137836266-137844052 (+)
A/J	MGP_AJ_G0016483	protein coding gene	Chr1:132654919-132662636 (+)
AKR/J	MGP_AKRJ_G0016448	protein coding gene	Chr1:136613781-136621554 (+)
BALB/cJ	MGP_BALBcJ_G0016443	protein coding gene	Chr1:132990529-132998313 (+)
C3H/HeJ	MGP_C3HHeJ_G0016269	protein coding gene	Chr1:136713724-136721508 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016904	protein coding gene	Chr1:142866458-142874242 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014615	protein coding gene	Chr1:125796850-125804863 (+)
CAST/EiJ	MGP_CASTEiJ_G0015849	protein coding gene	Chr1:135761751-135769467 (+)
CBA/J	MGP_CBAJ_G0016242	protein coding gene	Chr1:147806840-147814634 (+)
DBA/2J	MGP_DBA2J_G0016348	protein coding gene	Chr1:131667335-131675108 (+)
FVB/NJ	MGP_FVBNJ_G0016347	protein coding gene	Chr1:130293814-130301589 (+)
LP/J	MGP_LPJ_G0016419	protein coding gene	Chr1:139115258-139123042 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016372	protein coding gene	Chr1:153513225-153521019 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016940	protein coding gene	Chr1:136339998-136347785 (+)
PWK/PhJ	MGP_PWKPhJ_G0015635	protein coding gene	Chr1:130686070-130693798 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015422	protein coding gene	Chr1:135309981-135317779 (+)
WSB/EiJ	MGP_WSBEiJ_G0015912	protein coding gene	Chr1:136373081-136380804 (+)

Human Ortholog

MYBPH, myosin binding protein H

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYBPH, myosin binding protein H
Links

HGNC:7552

NCBI Gene ID: 4608

neXtProt AC: NX_Q13203

UniProt: Q13203
Chr Location

1q32.1; chr1:203167811-203179214 (-) GRCh38

MGI Vertebrate Homology

Mybph stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MYBPH
Gene Tree

Mybph

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Mybph
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

780
Tissues

10
cDNA Data

8
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MYBPHL

Xenbase mybph

ZFIN mybpha, mybphb

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All Sequences

42
RefSeq

8
UniProt

3
CCDS

CCDS35713.1

Ensembl

ENSMUSG00000042451 (Evidence)
NCBI Gene

53311

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042451	Ensembl Gene Model \| MGI Sequence Detail	7785	C57BL/6J	± kb
transcript	ENSMUST00000191577	Ensembl \| MGI Sequence Detail	2320	Not Applicable
polypeptide	ENSMUSP00000141104	Ensembl \| MGI Sequence Detail	483	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010806 myosin-binding protein H

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR050964 Striated Muscle Structural and Regulatory Protein
GlyGen

P70402 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 4

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MGI:2138220

Summaries

All 30

Developmental Gene Expression 3

Gene Ontology 2

Phenotypes 8
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:238742 Hayashi S, et al., Klf5 regulates muscle differentiation by directly targeting muscle-specific genes in cooperation with MyoD in mice. Elife. 2016 Oct 15;5:e17462

TSS for Mybph:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8866	Chr1:134121170-134121183 (+)	-9 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24