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Clpp Gene Detail
Summary
  • Symbol
    Clpp
  • Name
    caseinolytic mitochondrial matrix peptidase proteolytic subunit
  • Synonyms
    D17Wsu160e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858213
    NCBI Gene: 53895
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57297305-57303188 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.61 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    314 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858213
 protein coding gene Chr17:57297264-57303371 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023945
 protein coding gene Chr17:58734672-58740750 (+)
A/J MGP_AJ_G0023903
 protein coding gene Chr17:57111586-57117693 (+)
AKR/J MGP_AKRJ_G0023872
 protein coding gene Chr17:57834465-57840572 (+)
BALB/cJ MGP_BALBcJ_G0023904
 protein coding gene Chr17:56952042-56958149 (+)
C3H/HeJ MGP_C3HHeJ_G0023668
 protein coding gene Chr17:58556657-58562820 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024350
 protein coding gene Chr17:60998299-61004406 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021796
 protein coding gene Chr17:53591672-53597491 (+)
CAST/EiJ MGP_CASTEiJ_G0023150
 protein coding gene Chr17:58846010-58852031 (+)
CBA/J MGP_CBAJ_G0023644
 protein coding gene Chr17:63398099-63404192 (+)
DBA/2J MGP_DBA2J_G0023772
 protein coding gene Chr17:55809187-55815294 (+)
FVB/NJ MGP_FVBNJ_G0023738
 protein coding gene Chr17:55378697-55385605 (+)
LP/J MGP_LPJ_G0023854
 protein coding gene Chr17:59412360-59419157 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023766
 protein coding gene Chr17:62843218-62849296 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024394
 protein coding gene Chr17:58195569-58201676 (+)
PWK/PhJ MGP_PWKPhJ_G0022896
 protein coding gene Chr17:55176780-55183153 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022707
 protein coding gene Chr17:54962318-54970874 (+)
WSB/EiJ MGP_WSBEiJ_G0023216
 protein coding gene Chr17:58812132-58818091 (+)



Homology
more
  • Human Ortholog
    CLPP, caseinolytic mitochondrial matrix peptidase proteolytic subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLPP, caseinolytic mitochondrial matrix peptidase proteolytic subunit
  • Synonyms
    DFNB81, PRLTS3
  • Links
    NCBI Gene ID: 8192
    neXtProt AC: NX_Q16740
    UniProt: Q16740

  • Chr Location
    19p13.3; chr19:6361531-6370242 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Clpp mouse models; 1 with human CLPP associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotypes from 3 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit infertility, hearing loss, growth retardation, reduced activity, T cell activation, increased mitochondrial DNA and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    15
  • cDNA Data
    84
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002660 Ensembl Gene Model | MGI Sequence Detail 5884 C57BL/6J ±  kb
    transcript ENSMUST00000002735 Ensembl | MGI Sequence Detail 983 Not Applicable  
    polypeptide ENSMUSP00000002735 Ensembl | MGI Sequence Detail 272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000029361 ATP-dependent Clp protease proteolytic subunit, mitochondrial
      (term hierarchy)
    • EC
      3.4.21.92
    • InterPro Domains
      IPR001907 ATP-dependent Clp protease proteolytic subunit
      IPR029045 ClpP/crotonase-like domain superfamily
      IPR033135 ClpP, histidine active site
      IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA
      IPR018215 ClpP, Ser active site
    • GlyGen
      O88696 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 84
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36154, MGI:107582, MGI:2146982
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 10
      Phenotypes 25
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:353791 Xu L, et al., Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells. Cell Stem Cell. 2024 Aug 16;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory