Rcan2 MGI Mouse Gene Detail - MGI:1858219 - regulator of calcineurin 2

Symbol

Rcan2
Name

regulator of calcineurin 2
Synonyms

Csp2, Dscr1l1, MCIP2, ZAKI-4

Feature Type

protein coding gene
IDs

MGI:1858219
NCBI Gene: 53901
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr17:44112243-44350407 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 19.77 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

7551 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858219	protein coding gene	Chr17:44112242-44350407 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023780	protein coding gene	Chr17:44716680-44971364 (+)
A/J	MGP_AJ_G0023738	protein coding gene	Chr17:43695568-43935093 (+)
AKR/J	MGP_AKRJ_G0023709	protein coding gene	Chr17:43951758-44200301 (+)
BALB/cJ	MGP_BALBcJ_G0023742	protein coding gene	Chr17:43585676-43814689 (+)
C3H/HeJ	MGP_C3HHeJ_G0023506	protein coding gene	Chr17:44654873-44908628 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024185	protein coding gene	Chr17:46697094-46967925 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021635	protein coding gene	Chr17:40531553-40755417 (+)
CAST/EiJ	MGP_CASTEiJ_G0022987	protein coding gene	Chr17:44700912-44956872 (+)
CBA/J	MGP_CBAJ_G0023482	protein coding gene	Chr17:48350940-48608505 (+)
DBA/2J	MGP_DBA2J_G0023608	protein coding gene	Chr17:42504873-42738555 (+)
FVB/NJ	MGP_FVBNJ_G0023575	protein coding gene	Chr17:42076853-42308382 (+)
LP/J	MGP_LPJ_G0023689	protein coding gene	Chr17:45379173-45626820 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023604	protein coding gene	Chr17:47983749-48238805 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024230	protein coding gene	Chr17:44304145-44549782 (+)
PWK/PhJ	MGP_PWKPhJ_G0022732	protein coding gene	Chr17:41759622-42000792 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022547	protein coding gene	Chr17:41170290-41413325 (+)
WSB/EiJ	MGP_WSBEiJ_G0023052	protein coding gene	Chr17:44827666-45072060 (+)

Human Ortholog

RCAN2, regulator of calcineurin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RCAN2, regulator of calcineurin 2
Synonyms

CSP2, DSCR1L1, MCIP2, RCN2, ZAKI-4, ZAKI4
Links

HGNC:3041

NCBI Gene ID: 10231

neXtProt AC: NX_Q14206

UniProt: Q14206
Chr Location

6p12.3; chr6:46220736-46491972 (-) GRCh38

MGI Vertebrate Homology

Rcan2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RCAN2
Gene Tree

Rcan2

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
15 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

5
Gene trapped

2
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out alle exhibit decreased body weight and resistance to diet-induced obesity, steatosis, glucose intolerance, and insulin sensitivity.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

837
Tissues

76
cDNA Data

33
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rcan2

ZFIN rcan2

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All Sequences

67
RefSeq

10
UniProt

6
CCDS

CCDS28800.1, CCDS28801.1

Ensembl

ENSMUSG00000039601 (Evidence)
NCBI Gene

53901

			Length	Strain/Species	Flank
genomic	53901	NCBI Gene Model \| MGI Sequence Detail	238165	C57BL/6J	± kb
transcript	NM_001357742	RefSeq \| MGI Sequence Detail	3458	ZRU/MplStud
polypeptide	Q9JHG2	UniProt \| EBI \| MGI Sequence Detail	197	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013830 calcipressin-2

(term hierarchy)
InterPro Domains

IPR006931 Calcipressin

IPR034919 Calcipressin-2, RNA recognition motif

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

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All nucleic 40

cDNA 33

Primer pair 6

Other 1

Microarray probesets 5

Summaries

All 46

Developmental Gene Expression 10

Gene Ontology 4

Phenotypes 11
Earliest

J:61529 Strippoli P, et al., A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). Genomics. 2000 Mar 15;64(3):252-63
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Rcan2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144719	Chr17:44112185-44112213 (+)	-44 bp
Tssr144720	Chr17:44112215-44112245 (+)	-13 bp
Tssr144721	Chr17:44112679-44112708 (+)	451 bp
Tssr144722	Chr17:44112714-44112754 (+)	491 bp
Tssr144723	Chr17:44112761-44112773 (+)	524 bp
Tssr144724	Chr17:44112782-44112790 (+)	543 bp
Tssr144725	Chr17:44112804-44112815 (+)	567 bp
Tssr144726	Chr17:44112818-44112902 (+)	617 bp
Tssr144727	Chr17:44114912-44114932 (+)	2,679 bp
Tssr144728	Chr17:44114935-44114979 (+)	2,714 bp
Tssr144729	Chr17:44219520-44219542 (+)	107,288 bp
Tssr144730	Chr17:44219986-44219999 (+)	107,750 bp
Tssr144731	Chr17:44263936-44263954 (+)	151,702 bp
Tssr144732	Chr17:44264131-44264167 (+)	151,906 bp
Tssr144733	Chr17:44264249-44264260 (+)	152,012 bp
Tssr144734	Chr17:44295912-44295924 (+)	183,675 bp
Tssr144735	Chr17:44337564-44337584 (+)	225,331 bp
Tssr144736	Chr17:44349757-44349771 (+)	237,521 bp
Tssr144737	Chr17:44349866-44349878 (+)	237,629 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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