Ear4 Gene Detail

Summary

• Symbol
  Ear4
• Name
  eosinophil-associated, ribonuclease A family, member 4
• Synonyms
  liver, eosinophil-derived neurotoxin, mR4, ribonuclease 4

• Feature Type
  protein coding gene
• IDs
  MGI:1858238
  NCBI Gene: 53877
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr14:51441154-51441613 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 14, cytoband C1
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  104 from dbSNP Build 142
• Strain Annotations
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858238	protein coding gene	Chr14:51441154-51441613 (.)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Homology

• Human Ortholog
  RNASE2, ribonuclease A family member 2

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  RNASE2, ribonuclease A family member 2
  
• Synonyms
  EDN, RAF3, RNS2
• Links
  HGNC:10045

  NCBI Gene ID: 6036

  neXtProt AC: NX_P10153

  UniProt: P10153

  
  
• Chr Location
  14q11.2; chr14:20955487-20956436 (+)  GRCh38

---

• Human Ortholog
  RNASE3, ribonuclease A family member 3
  
• Synonyms
  ECP, RAF1, RNS3
• Links
  HGNC:10046

  NCBI Gene ID: 6037

  neXtProt AC: NX_P12724

  UniProt: P12724

  
  
• Chr Location
  14q11.2; chr14:20891385-20892348 (+)  GRCh38

---

• MGI Vertebrate Homology
  Ear4 stringent orthology
  2 human;1 mouse;2 rat
  
• HCOP
  vertebrate homology predictions: RNASE2, RNASE3

Mutations,
Alleles, and
Phenotypes

• Incidental Mutations
  APF
• Find Mice (IMSR)
  0 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  12
• GO References
  6

Expression

• Other Mouse Links
  GEO

Sequences &
Gene Models

• All Sequences
  5
• RefSeq
  2
• UniProt
  1

• NCBI Gene
  53877

Representative Sequences			Length	Strain/Species
genomic	AF017259	GenBank | ENA | DDBJ | MGI Sequence Detail	468	Not Specified
transcript	NM_001017422	RefSeq | MGI Sequence Detail	468	Not Specified
polypeptide	O35291	UniProt | EBI | MGI Sequence Detail	155	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• EC
  4.6.1.18
• InterPro Domains
  IPR001427 Pancreatic ribonuclease
  IPR023411 Ribonuclease A, active site
  IPR023412 Ribonuclease A-domain
  IPR036816 Ribonuclease A-like domain superfamily
• GlyGen
  O35291 4 sites

Molecular
Reagents

• 
  

  Microarray probesets 1

References

• Summaries
  All 15

  Gene Ontology 6
• Earliest
  J:44252 Batten D, et al., Molecular cloning of four novel murine ribonuclease genes: unusual expansion within the ribonuclease A gene family. Nucleic Acids Res. 1997 Nov 1;25(21):4235-9
• Latest
  J:95949 Cho S, et al., The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. Genomics. 2005 Feb;85(2):208-20