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Pgrmc1 Gene Detail
Summary
  • Symbol
    Pgrmc1
  • Name
    progesterone receptor membrane component 1
  • Synonyms
    HPR6.6, PPMR, Vema
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858305
    NCBI Gene: 53328
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:35861859-35869732 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 21.00 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858305
 protein coding gene ChrX:35861846-35869732 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035621
 protein coding gene ChrX:31513555-31521435 (+)
A/J MGP_AJ_G0035598
 protein coding gene ChrX:31591834-31600429 (+)
AKR/J MGP_AKRJ_G0035531
 protein coding gene ChrX:32272973-32281401 (+)
BALB/cJ MGP_BALBcJ_G0035591
 protein coding gene ChrX:31327424-31335972 (+)
C3H/HeJ MGP_C3HHeJ_G0035309
 protein coding gene ChrX:31824422-31835021 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036127
 protein coding gene ChrX:32144844-32153222 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032989
 protein coding gene ChrX:29827492-29835592 (+)
CAST/EiJ MGP_CASTEiJ_G0034600
 protein coding gene ChrX:19990234-19998138 (+)
CBA/J MGP_CBAJ_G0035278
 protein coding gene ChrX:33010259-33018938 (+)
DBA/2J MGP_DBA2J_G0035430
 protein coding gene ChrX:31422214-31430633 (+)
FVB/NJ MGP_FVBNJ_G0035376
 protein coding gene ChrX:31186363-31194232 (+)
LP/J MGP_LPJ_G0035512
 protein coding gene ChrX:31872892-31880765 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035420
 protein coding gene ChrX:33462804-33472538 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036134
 protein coding gene ChrX:31495080-31503062 (+)
PWK/PhJ MGP_PWKPhJ_G0034301
 protein coding gene ChrX:19467160-19475120 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034142
 protein coding gene ChrX:20482014-20489907 (+)
WSB/EiJ MGP_WSBEiJ_G0034735
 protein coding gene ChrX:31286660-31295640 (+)



Homology
more
  • Human Ortholog
    PGRMC1, progesterone receptor membrane component 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGRMC1, progesterone receptor membrane component 1
  • Synonyms
    Dap1, HPR6.6, IZA, MPR
  • Links
    NCBI Gene ID: 10857
    neXtProt AC: NX_O00264
    UniProt: O00264

  • Chr Location
    Xq24; chrX:119236245-119244466 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pgrmc1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in vomeronasal sensory neurons exhibit constant attraction behavior to recombinant major urinary proteins (rMUPs). in both estrus and diestrus females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    909
  • Tissues
    139
  • cDNA Data
    230
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006373 Ensembl Gene Model | MGI Sequence Detail 7874 C57BL/6J ±  kb
    transcript ENSMUST00000073339 Ensembl | MGI Sequence Detail 1857 Not Applicable  
    polypeptide ENSMUSP00000073061 Ensembl | MGI Sequence Detail 195 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000012622 membrane-associated progesterone receptor component 1
      (term hierarchy)
    • InterPro Domains
      IPR001199 Cytochrome b5-like heme/steroid binding domain
      IPR036400 Cytochrome b5-like heme/steroid binding domain superfamily
      IPR050577 Cytochrome b5/MAPR and VMP1 families
    • GlyGen
      O55022 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 233
      cDNA 230
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147828
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 9
      Phenotypes 18
    • Earliest
      J:66059 Nolte I, et al., Localization and topology of ratp28, a member of a novel family of putative steroid-binding proteins. Biochim Biophys Acta. 2000 Nov 30;1543(1):123-30
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory