Tnk2 MGI Mouse Gene Detail - MGI:1858308 - tyrosine kinase, non-receptor, 2

Symbol

Tnk2
Name

tyrosine kinase, non-receptor, 2
Synonyms

Ack, ACK1, activated p21cdc42Hs kinase, P21cdc42Hs kinase, Pyk1

Feature Type

protein coding gene
IDs

MGI:1858308
NCBI Gene: 51789
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr16:32462699-32502311 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 23.16 cM
Mapping Data

2 experiments

SNPs within 2kb

912 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858308	protein coding gene	Chr16:32462692-32502311 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022743	protein coding gene	Chr16:30738837-30784671 (+)
A/J	MGP_AJ_G0022708	protein coding gene	Chr16:29272937-29313466 (+)
AKR/J	MGP_AKRJ_G0022681	protein coding gene	Chr16:30336281-30379694 (+)
BALB/cJ	MGP_BALBcJ_G0022710	protein coding gene	Chr16:29420115-29460260 (+)
C3H/HeJ	MGP_C3HHeJ_G0022475	protein coding gene	Chr16:30461744-30501205 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023159	protein coding gene	Chr16:31394134-31438205 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020677	protein coding gene	Chr16:29650624-29690446 (+)
CAST/EiJ	MGP_CASTEiJ_G0022003	protein coding gene	Chr16:30602032-30643576 (+)
CBA/J	MGP_CBAJ_G0022445	protein coding gene	Chr16:32648024-32691707 (+)
DBA/2J	MGP_DBA2J_G0022578	protein coding gene	Chr16:29119479-29159910 (+)
FVB/NJ	MGP_FVBNJ_G0022553	protein coding gene	Chr16:29106056-29146512 (+)
LP/J	MGP_LPJ_G0022645	protein coding gene	Chr16:30489013-30532016 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022572	protein coding gene	Chr16:32065551-32110204 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023171	protein coding gene	Chr16:30315966-30358011 (+)
PWK/PhJ	MGP_PWKPhJ_G0021742	protein coding gene	Chr16:29448058-29488425 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021573	protein coding gene	Chr16:30114200-30158395 (+)
WSB/EiJ	MGP_WSBEiJ_G0022047	protein coding gene	Chr16:30273073-30316783 (+)

Human Ortholog

TNK2, tyrosine kinase non receptor 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNK2, tyrosine kinase non receptor 2
Synonyms

ACK, ACK-1, ACK1, p21cdc42Hs
Links

HGNC:19297

NCBI Gene ID: 10188

neXtProt AC: NX_Q07912

UniProt: Q07912
Chr Location

3q29; chr3:195863364-195911945 (-) GRCh38

MGI Vertebrate Homology

Tnk2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TNK2
Gene Tree

Tnk2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Endonuclease-mediated

3
Gene trapped

28
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

76
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1419
Tissues

273
cDNA Data

110
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tnk2

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All Sequences

146
RefSeq

52
UniProt

20
CCDS

CCDS37313.1, CCDS49828.1, CCDS84224.1

Ensembl

ENSMUSG00000022791 (Evidence)
NCBI Gene

51789

			Length	Strain/Species	Flank
genomic	51789	NCBI Gene Model \| MGI Sequence Detail	39613	C57BL/6J	± kb
transcript	NM_016788	RefSeq \| MGI Sequence Detail	4454	C57BL/6
polypeptide	O54967	UniProt \| EBI \| MGI Sequence Detail	1055	Not Applicable

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UniProt

20 Sequences
Protein Ontology

PR:000016496 activated CDC42 kinase 1

(term hierarchy)
EC

2.7.10.2, 2.7.11.1
InterPro Domains

IPR030220 Activated CDC42 kinase 1, UBA domain

IPR015116 Cdc42 binding domain-like

IPR037085 Cdc42 binding domain-like superfamily

IPR052112 EGFR Signaling Regulator Kinase

IPR021619 Mig-6 domain

IPR050198 Non-receptor tyrosine kinases involved in cell signaling

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR013761 Sterile alpha motif/pointed domain superfamily

IPR049587 TNK(ACK)-like non-receptor tyrosine-protein kinases, SAM domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR009060 UBA-like superfamily
GlyGen

O54967 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 111

Genomic 1

cDNA 110

Microarray probesets 4

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MGI:2146660

Summaries

All 57

Developmental Gene Expression 6

Gene Ontology 17

Phenotypes 12
Earliest

J:44192 Gertler FB, et al., Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell. 1996 Oct 18;87(2):227-39
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tnk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138017	Chr16:32462665-32462734 (+)	1 bp
Tssr138018	Chr16:32462928-32462963 (+)	247 bp
Tssr138019	Chr16:32469342-32469346 (+)	6,645 bp
Tssr138020	Chr16:32469589-32469593 (+)	6,892 bp
Tssr138021	Chr16:32477722-32477767 (+)	15,046 bp
Tssr138022	Chr16:32480041-32480063 (+)	17,353 bp
Tssr138023	Chr16:32489605-32489606 (+)	26,907 bp
Tssr138024	Chr16:32491962-32492006 (+)	29,285 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24