About   Help   FAQ
Sec61a1 Gene Detail
Summary
  • Symbol
    Sec61a1
  • Name
    SEC61 translocon subunit alpha 1
  • Synonyms
    Sec61a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858417
    NCBI Gene: 53421
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:88480589-88495782 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 39.51 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    455 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858417
 protein coding gene Chr6:88480561-88495887 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031011
 protein coding gene Chr6:89900994-89918031 (-)
A/J MGP_AJ_G0030977
 protein coding gene Chr6:86445742-86461199 (-)
AKR/J MGP_AKRJ_G0030908
 protein coding gene Chr6:88932934-88948258 (-)
BALB/cJ MGP_BALBcJ_G0030990
 protein coding gene Chr6:86438494-86454203 (-)
C3H/HeJ MGP_C3HHeJ_G0030720
 protein coding gene Chr6:95504840-95520834 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031447
 protein coding gene Chr6:92328328-92345990 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028629
 protein coding gene Chr6:84601089-84616533 (-)
CAST/EiJ MGP_CASTEiJ_G0030099
 protein coding gene Chr6:89027099-89043542 (-)
CBA/J MGP_CBAJ_G0030674
 protein coding gene Chr6:95875985-95891288 (-)
DBA/2J MGP_DBA2J_G0030830
 protein coding gene Chr6:85732925-85748286 (-)
FVB/NJ MGP_FVBNJ_G0030783
 protein coding gene Chr6:84926393-84942428 (-)
LP/J MGP_LPJ_G0030907
 protein coding gene Chr6:89939707-89955933 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030816
 protein coding gene Chr6:99980075-99997067 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031474
 protein coding gene Chr6:88785787-88802286 (-)
PWK/PhJ MGP_PWKPhJ_G0029814
 protein coding gene Chr6:84712363-84727699 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029642
 protein coding gene Chr6:87596125-87611303 (-)
WSB/EiJ MGP_WSBEiJ_G0030180
 protein coding gene Chr6:89238835-89254149 (-)



Homology
more
  • Human Ortholog
    SEC61A1, SEC61 translocon subunit alpha 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEC61A1, SEC61 translocon subunit alpha 1
  • Synonyms
    ADTKD5, CVID15, HNFJ4, HSEC61, SEC61, SEC61A
  • Links
    NCBI Gene ID: 29927
    neXtProt AC: NX_P61619
    UniProt: P61619

  • Chr Location
    3q21.3; chr3:128051641-128071705 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human SEC61A1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit decreased body weight, hyperglycemia, hypoinsulinemia, impaired glucose tolerance, apoptosis of beta-cells, and enlarged and pale liver with hepatic steatosis and cirrhosis when fed a high fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    11
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53421 NCBI Gene Model | MGI Sequence Detail 15194 C57BL/6J ±  kb
    transcript NM_016906 RefSeq | MGI Sequence Detail 3045 C57BL/6  
    polypeptide P61620 UniProt | EBI | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1353628, MGI:2141359
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:77390 Dudek J, et al., A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes. EMBO J. 2002 Jun 17;21(12):2958-67
    • Latest
      J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory