Mcrs1 MGI Mouse Gene Detail - MGI:1858420

Symbol

Mcrs1
Name

microspherule protein 1
Synonyms

C78274, ICP22BP, MSP58, P78

Feature Type

protein coding gene
IDs

MGI:1858420
NCBI Gene: 51812
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:99140698-99149838 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.09 cM
Mapping Data

1 experiment

SNPs within 2kb

258 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858420	protein coding gene	Chr15:99140698-99149842 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022326	protein coding gene	Chr15:101062738-101071866 (-)
A/J	MGP_AJ_G0022284	protein coding gene	Chr15:97047392-97055049 (-)
AKR/J	MGP_AKRJ_G0022260	protein coding gene	Chr15:100040767-100048424 (-)
BALB/cJ	MGP_BALBcJ_G0022290	protein coding gene	Chr15:97236599-97245179 (-)
C3H/HeJ	MGP_C3HHeJ_G0022058	protein coding gene	Chr15:100102565-100112982 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022735	protein coding gene	Chr15:104842007-104849664 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020261	protein coding gene	Chr15:92945375-92955069 (-)
CAST/EiJ	MGP_CASTEiJ_G0021582	protein coding gene	Chr15:100952186-100961274 (-)
CBA/J	MGP_CBAJ_G0022027	protein coding gene	Chr15:108397962-108409998 (-)
DBA/2J	MGP_DBA2J_G0022154	protein coding gene	Chr15:96491868-96501003 (-)
FVB/NJ	MGP_FVBNJ_G0022134	protein coding gene	Chr15:95474820-95483957 (-)
LP/J	MGP_LPJ_G0022225	protein coding gene	Chr15:101204717-101213845 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022154	protein coding gene	Chr15:112339118-112348258 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022750	protein coding gene	Chr15:100135551-100145737 (-)
PWK/PhJ	MGP_PWKPhJ_G0021321	protein coding gene	Chr15:96622495-96632187 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021156	protein coding gene	Chr15:99988141-99997284 (-)
WSB/EiJ	MGP_WSBEiJ_G0021633	protein coding gene	Chr15:100669271-100678436 (-)

Human Ortholog

MCRS1, microspherule protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MCRS1, microspherule protein 1
Synonyms

ICP22BP, INO80Q, MCRS2, MSP58, P78
Links

HGNC:6960

NCBI Gene ID: 10445

neXtProt AC: NX_Q96EZ8

UniProt: Q96EZ8
Chr Location

12q13.12; chr12:49556544-49568145 (-) GRCh38

MGI Vertebrate Homology

Mcrs1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MCRS1
Gene Tree

Mcrs1

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References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 3 alleles in 3 genetic backgrounds
1 images
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

35
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

25
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Mcrs1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit normal blastocyst formation but fail to implant and show pre-implantation lethality with a severe reduction in inner cell mass and epiblast cell number but normal specification of the trophoblast and primitive endoderm.

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All GO Annotations

54
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

838
Tissues

83
cDNA Data

11
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mcrs1

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All Sequences

71
RefSeq

6
UniProt

7
CCDS

CCDS37199.1, CCDS49728.1

Ensembl

ENSMUSG00000037570 (Evidence)
NCBI Gene

51812

			Length	Strain/Species	Flank
genomic	51812	NCBI Gene Model \| MGI Sequence Detail	9141	C57BL/6J	± kb
transcript	NM_001411911	RefSeq \| MGI Sequence Detail	2052	C57BL/6
polypeptide	Q99L90	UniProt \| EBI \| MGI Sequence Detail	462	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000010256 microspherule protein 1

(term hierarchy)
InterPro Domains

IPR000253 Forkhead-associated (FHA) domain

IPR037912 Microspherule protein 1

IPR025999 Microspherule protein, N-terminal domain

IPR008984 SMAD/FHA domain superfamily
GlyGen

Q99L90 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 13

cDNA 11

Primer pair 2

Microarray probesets 3

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MGI:2146281

Summaries

All 67

Developmental Gene Expression 8

Diseases 1

Gene Ontology 8

Phenotypes 35
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mcrs1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136354	Chr15:99149810-99149849 (-)	8 bp
Tssr136353	Chr15:99149794-99149805 (-)	38 bp
Tssr136352	Chr15:99146833-99146853 (-)	2,995 bp
Tssr136351	Chr15:99146815-99146828 (-)	3,016 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24