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Copg1 Gene Detail
Summary
  • Symbol
    Copg1
  • Name
    coatomer protein complex, subunit gamma 1
  • Synonyms
    Copg, D6Ertd71e, D6Wsu16e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858696
    NCBI Gene: 54161
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:87864801-87890577 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 39.13 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    852 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858696
 protein coding gene Chr6:87864796-87890577 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031002
 protein coding gene Chr6:89260726-89286921 (+)
A/J MGP_AJ_G0030968
 protein coding gene Chr6:85817105-85843098 (+)
AKR/J MGP_AKRJ_G0030899
 protein coding gene Chr6:88297036-88322805 (+)
BALB/cJ MGP_BALBcJ_G0030981
 protein coding gene Chr6:85807489-85833060 (+)
C3H/HeJ MGP_C3HHeJ_G0030729
 protein coding gene Chr6:96149059-96177841 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031438
 protein coding gene Chr6:91646963-91673732 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028621
 protein coding gene Chr6:83986412-84013666 (+)
CAST/EiJ MGP_CASTEiJ_G0030090
 protein coding gene Chr6:88376078-88401494 (+)
CBA/J MGP_CBAJ_G0030665
 protein coding gene Chr6:95195975-95221693 (+)
DBA/2J MGP_DBA2J_G0030821
 protein coding gene Chr6:85112363-85137950 (+)
FVB/NJ MGP_FVBNJ_G0030774
 protein coding gene Chr6:84302848-84328671 (+)
LP/J MGP_LPJ_G0030898
 protein coding gene Chr6:89277575-89303293 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030807
 protein coding gene Chr6:99328872-99354399 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031465
 protein coding gene Chr6:88150814-88176348 (+)
PWK/PhJ MGP_PWKPhJ_G0029805
 protein coding gene Chr6:84083482-84109882 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029633
 protein coding gene Chr6:86959072-86986199 (+)
WSB/EiJ MGP_WSBEiJ_G0030171
 protein coding gene Chr6:88598435-88624090 (+)



Homology
more
  • Human Ortholog
    COPG1, COPI coat complex subunit gamma 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COPG1, COPI coat complex subunit gamma 1
  • Synonyms
    COPG, IMD128
  • Links
    NCBI Gene ID: 22820
    neXtProt AC: NX_Q9Y678
    UniProt: Q9Y678

  • Chr Location
    3q21.3; chr3:129249606-129277773 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Copg1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygosity for the p.K652E mutation increases ER stress in B cells and impairs immune response to bacterial infections, leading to weight loss, hunched posture and ruffled fur.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    864
  • Tissues
    105
  • cDNA Data
    335
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54161 NCBI Gene Model | MGI Sequence Detail 25777 C57BL/6J ±  kb
    transcript NM_017477 RefSeq | MGI Sequence Detail 4014 ZRU/MplStud  
    polypeptide Q9QZE5 UniProt | EBI | MGI Sequence Detail 874 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 340
      cDNA 337
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-34156, MGI:106462, MGI:1098809, MGI:2141561, MGI:3036293
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory