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Septin1 Gene Detail
Summary
  • Symbol
    Septin1
  • Name
    septin 1
  • Synonyms
    Diff6, PNUTL3, Sept1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858916
    NCBI Gene: 54204
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126813619-126832302 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.39 cM, cytoband F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    483 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858916
 protein coding gene Chr7:126811881-126832302 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033026
 protein coding gene Chr7:131548725-131568654 (-)
A/J MGP_AJ_G0033009
 protein coding gene Chr7:128046110-128064716 (-)
AKR/J MGP_AKRJ_G0032941
 protein coding gene Chr7:131296081-131317936 (-)
BALB/cJ MGP_BALBcJ_G0033014
 protein coding gene Chr7:127707599-127726515 (-)
C3H/HeJ MGP_C3HHeJ_G0032724
 protein coding gene Chr7:131232422-131252521 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033520
 protein coding gene Chr7:136658059-136677773 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030492
 protein coding gene Chr7:129259665-129277535 (-)
CAST/EiJ MGP_CASTEiJ_G0032053
 protein coding gene Chr7:123027851-123047165 (-)
CBA/J MGP_CBAJ_G0032697
 protein coding gene Chr7:141258145-141279479 (-)
DBA/2J MGP_DBA2J_G0032849
 protein coding gene Chr7:126017611-126036561 (-)
FVB/NJ MGP_FVBNJ_G0032802
 protein coding gene Chr7:125870971-125889535 (-)
LP/J MGP_LPJ_G0032943
 protein coding gene Chr7:133013003-133031744 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032834
 protein coding gene Chr7:142403851-142425406 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033539
 protein coding gene Chr7:130309952-130333020 (-)
PWK/PhJ MGP_PWKPhJ_G0031760
 protein coding gene Chr7:119026215-119045717 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031606
 protein coding gene Chr7:117147868-117167887 (-)
WSB/EiJ MGP_WSBEiJ_G0032165
 protein coding gene Chr7:131284914-131305878 (-)



Homology
more
  • Human Ortholog
    SEPTIN1, septin 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEPTIN1, septin 1
  • Synonyms
    DIFF6, LARP, PNUTL3, SEP1, SEPT1, Septin-1
  • Links
    NCBI Gene ID: 1731
    neXtProt AC: NX_Q8WYJ6
    UniProt: Q8WYJ6

  • Chr Location
    16p11.2; chr16:30378135-30395991 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    26
  • cDNA Data
    23
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000486 Ensembl Gene Model | MGI Sequence Detail 18684 C57BL/6J ±  kb
transcript ENSMUST00000106314 Ensembl | MGI Sequence Detail 1486 Not Applicable  
polypeptide ENSMUSP00000101921 Ensembl | MGI Sequence Detail 366 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 23
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:6368826
References
more
  • Summaries
    All 66
    Developmental Gene Expression 4
    Diseases 2
    Gene Ontology 6
    Phenotypes 37
  • Earliest
    J:25671 Nottenburg C, et al., Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences. Gene. 1990 Nov 15;95(2):279-84
  • Latest
    J:349484 Henis M, et al., The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation. Sci Adv. 2024 Apr 12;10(15):eadf7001
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory