About   Help   FAQ
Arl6ip1 Gene Detail
Summary
  • Symbol
    Arl6ip1
  • Name
    ADP-ribosylation factor-like 6 interacting protein 1
  • Synonyms
    AIP-6, ARMER, mKIAA0069
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858943
    NCBI Gene: 54208
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:117718113-117728848 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 63.44 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    278 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858943
 protein coding gene Chr7:117718113-117728885 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032895
 protein coding gene Chr7:121928631-121940751 (-)
A/J MGP_AJ_G0032878
 protein coding gene Chr7:118854514-118864373 (-)
AKR/J MGP_AKRJ_G0032810
 protein coding gene Chr7:121864312-121878146 (-)
BALB/cJ MGP_BALBcJ_G0032883
 protein coding gene Chr7:118577317-118587695 (-)
C3H/HeJ MGP_C3HHeJ_G0032593
 protein coding gene Chr7:121788212-121799004 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033389
 protein coding gene Chr7:126796053-126808543 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030361
 protein coding gene Chr7:120321324-120331120 (-)
CAST/EiJ MGP_CASTEiJ_G0031921
 protein coding gene Chr7:113520740-113536660 (-)
CBA/J MGP_CBAJ_G0032566
 protein coding gene Chr7:131018819-131032960 (-)
DBA/2J MGP_DBA2J_G0032718
 protein coding gene Chr7:116893263-116903186 (-)
FVB/NJ MGP_FVBNJ_G0032671
 protein coding gene Chr7:116733084-116745759 (-)
LP/J MGP_LPJ_G0032812
 protein coding gene Chr7:123407056-123419750 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032703
 protein coding gene Chr7:132556187-132567374 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033409
 protein coding gene Chr7:120864355-120876480 (-)
PWK/PhJ MGP_PWKPhJ_G0031629
 protein coding gene Chr7:109781934-109791959 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031476
 protein coding gene Chr7:107615168-107625100 (-)
WSB/EiJ MGP_WSBEiJ_G0032034
 protein coding gene Chr7:121753770-121767254 (-)



Homology
more
  • Human Ortholog
    ARL6IP1, ARL6 interacting reticulophagy regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARL6IP1, ARL6 interacting reticulophagy regulator 1
  • Synonyms
    AIP1, ARL6IP, ARMER, SPG61
  • Links
    NCBI Gene ID: 23204
    neXtProt AC: NX_Q15041
    UniProt: Q15041

  • Chr Location
    16p12.3; chr16:18791667-18801572 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ARL6IP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    42
  • cDNA Data
    373
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54208 NCBI Gene Model | MGI Sequence Detail 10736 C57BL/6J ±  kb
    transcript NM_019419 RefSeq | MGI Sequence Detail 2154 C57BL/6  
    polypeptide Q9JKW0 UniProt | EBI | MGI Sequence Detail 203 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000004291 ADP-ribosylation factor-like protein 6-interacting protein 1
      (term hierarchy)
    • InterPro Domains
      IPR052114 ER-associated autophagy and membrane dynamics regulator
    Molecular
    Reagents
    less
    • All nucleic 374
      cDNA 374

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142090, MGI:2142156, MGI:2142353
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:62458 Ingley E, et al., A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. FEBS Lett. 1999 Oct 1;459(1):69-74
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory