Azin1 MGI Mouse Gene Detail - MGI:1859169

Symbol

Azin1
Name

antizyme inhibitor 1
Synonyms

1700085L02Rik, Oazi, Oazin, ODC antizyme inhibitor

Feature Type

protein coding gene
IDs

MGI:1859169
NCBI Gene: 54375
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:38487671-38519510 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 15.17 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

732 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859169	protein coding gene	Chr15:38487671-38523506 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021808	protein coding gene	Chr15:37006658-37039515 (-)
A/J	MGP_AJ_G0021768	protein coding gene	Chr15:35575910-35607795 (-)
AKR/J	MGP_AKRJ_G0021749	protein coding gene	Chr15:36638461-36673936 (-)
BALB/cJ	MGP_BALBcJ_G0021775	protein coding gene	Chr15:35613131-35647685 (-)
C3H/HeJ	MGP_C3HHeJ_G0021549	protein coding gene	Chr15:36575683-36606638 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022214	protein coding gene	Chr15:38438287-38471232 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019751	protein coding gene	Chr15:33347645-33379112 (-)
CAST/EiJ	MGP_CASTEiJ_G0021066	protein coding gene	Chr15:36995767-37029683 (-)
CBA/J	MGP_CBAJ_G0021518	protein coding gene	Chr15:39666050-39700727 (-)
DBA/2J	MGP_DBA2J_G0021642	protein coding gene	Chr15:35410824-35445617 (-)
FVB/NJ	MGP_FVBNJ_G0021620	protein coding gene	Chr15:34817849-34849453 (-)
LP/J	MGP_LPJ_G0021712	protein coding gene	Chr15:36872094-36906439 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021644	protein coding gene	Chr15:42661944-42699150 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022237	protein coding gene	Chr15:36765575-36800842 (-)
PWK/PhJ	MGP_PWKPhJ_G0020810	protein coding gene	Chr15:35469626-35501333 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020648	protein coding gene	Chr15:36460878-36497659 (-)
WSB/EiJ	MGP_WSBEiJ_G0021121	protein coding gene	Chr15:36722503-36753518 (-)

Human Ortholog

AZIN1, antizyme inhibitor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AZIN1, antizyme inhibitor 1
Synonyms

AZI, AZI1, AZIA1, OAZI, OAZIN, ODC1L
Links

HGNC:16432

NCBI Gene ID: 51582

neXtProt AC: NX_O14977

UniProt: O14977
Chr Location

8q22.3; chr8:102826111-102893864 (-) GRCh38

MGI Vertebrate Homology

Azin1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: AZIN1
Gene Tree

Azin1

Diseases

3 with human AZIN1 associations

				Human Disease	Mouse Models
				esophagus squamous cell carcinoma IDs esophagus squamous cell carcinoma DOID:3748 MESH:D000077277 NCI:C4024 UMLS_CUI:C0279626
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				liver cirrhosis IDs liver cirrhosis DOID:5082 EFO:0001422 ICD10CM:K74.60 MESH:D008103 NCI:C2951 UMLS_CUI:C0023890

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

19
Targeted

2
Genomic Mutations

2 involving Azin1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous disruption of this gene results in neonatal lethality, a slight reduction in birth weight, and abnormal liver morphology.

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All GO Annotations

24
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

9
cDNA Data

22
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase azin1

ZFIN azin1a, azin1b

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All Sequences

80
RefSeq

15
UniProt

5
CCDS

CCDS37065.1

Ensembl

ENSMUSG00000037458 (Evidence)
NCBI Gene

54375

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037458	Ensembl Gene Model \| MGI Sequence Detail	31840	C57BL/6J	± kb
transcript	ENSMUST00000065308	Ensembl \| MGI Sequence Detail	4871	Not Applicable
polypeptide	ENSMUSP00000065544	Ensembl \| MGI Sequence Detail	448	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004533 antizyme inhibitor 1

(term hierarchy)
PDB

3BTN
InterPro Domains

IPR009006 Alanine racemase/group IV decarboxylase, C-terminal

IPR031178 Antizyme inhibitor 1

IPR022657 Orn/DAP/Arg decarboxylase 2, conserved site

IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal

IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal

IPR000183 Ornithine/DAP/Arg decarboxylase

IPR002433 Ornithine decarboxylase

IPR029066 PLP-binding barrel

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All nucleic 24

cDNA 23

Primer pair 1

Microarray probesets 5

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MGI:1920775, MGI:2145992

Summaries

All 49

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Azin1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134133	Chr15:38519499-38519515 (-)	3 bp
Tssr134132	Chr15:38518457-38518474 (-)	1,044 bp
Tssr134131	Chr15:38518435-38518456 (-)	1,064 bp
Tssr4581	Chr15:38515069-38515074 (-)	4,438 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24