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Dnmt3l Gene Detail
Summary
  • Symbol
    Dnmt3l
  • Name
    DNA methyltransferase 3-like
  • Synonyms
    D6Ertd14e, ecat7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859287
    NCBI Gene: 54427
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:77878121-77899456 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    563 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859287
 protein coding gene Chr10:77877781-77899456 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017415
 protein coding gene Chr10:78452072-78477671 (+)
A/J MGP_AJ_G0017393
 protein coding gene Chr10:75734010-75758464 (+)
AKR/J MGP_AKRJ_G0017356
 protein coding gene Chr10:77761734-77783303 (+)
BALB/cJ MGP_BALBcJ_G0017355
 protein coding gene Chr10:75907783-75930048 (+)
C3H/HeJ MGP_C3HHeJ_G0017178
 protein coding gene Chr10:77844283-77868219 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017811
 protein coding gene Chr10:81238456-81262344 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015502
 protein coding gene Chr10:72083678-72106331 (+)
CAST/EiJ MGP_CASTEiJ_G0016748
 protein coding gene Chr10:78171989-78194632 (+)
CBA/J MGP_CBAJ_G0017150
 protein coding gene Chr10:84315672-84354798 (+)
DBA/2J MGP_DBA2J_G0017258
 protein coding gene Chr10:74975238-74999345 (+)
FVB/NJ MGP_FVBNJ_G0017250
 protein coding gene Chr10:74160222-74182506 (+)
LP/J MGP_LPJ_G0017329
 protein coding gene Chr10:78903732-78930803 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017277
 protein coding gene Chr10:86313281-86338331 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017853
 protein coding gene Chr10:77805437-77829942 (+)
PWK/PhJ MGP_PWKPhJ_G0016530
 protein coding gene Chr10:74852028-74875728 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016315
 protein coding gene Chr10:77023511-77048481 (+)
WSB/EiJ MGP_WSBEiJ_G0016808
 protein coding gene Chr10:77777190-77801730 (+)



Homology
more
  • Human Ortholog
    DNMT3L, DNA methyltransferase 3 like
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNMT3L, DNA methyltransferase 3 like
  • Links
    NCBI Gene ID: 29947
    neXtProt AC: NX_Q9UJW3
    UniProt: Q9UJW3

  • Chr Location
    21q22.3; chr21:44246339-44262216 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 7 alleles in 7 genetic backgrounds
    10 phenotypes from multigenic genotypes
    1 images
    90 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutants in this imprinted gene lack appropriate methylation of the maternal allele and this, in turn, causes azoospermia in homozygous males; and heterozygous progeny of homozygous females die by midgestation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1167
  • Tissues
    199
  • cDNA Data
    29
  • Literature Summary
    69
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54427 NCBI Gene Model | MGI Sequence Detail 21336 C57BL/6J ±  kb
    transcript NM_001081695 RefSeq | MGI Sequence Detail 1831 ZRU/MplStud  
    polypeptide Q9CWR8 UniProt | EBI | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000006609 DNA (cytosine-5)-methyltransferase 3-like
      (term hierarchy)
    • InterPro Domains
      IPR025766 ADD domain
      IPR049554 DNMT3, ADD domain, PHD zinc finger
      IPR040552 DNMT3, cysteine rich ADD domain, GATA1-like zinc finger
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
      IPR011011 Zinc finger, FYVE/PHD-type
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 1
      cDNA 30
      Primer pair 15
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1098798
    References
    more
    • Summaries
      All 195
      Developmental Gene Expression 69
      Diseases 2
      Gene Ontology 18
      Phenotypes 90
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory