Syt10 MGI Mouse Gene Detail - MGI:1859546

Symbol

Syt10
Name

synaptotagmin X

Feature Type

protein coding gene
IDs

MGI:1859546
NCBI Gene: 54526
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:89666596-89726063 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 44.96 cM, cytoband F1
Mapping Data

1 experiment

SNPs within 2kb

1800 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859546	protein coding gene	Chr15:89657221-89726181 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022242	protein coding gene	Chr15:90997204-91066025 (-)
A/J	MGP_AJ_G0022201	protein coding gene	Chr15:87513160-87572594 (-)
AKR/J	MGP_AKRJ_G0022176	protein coding gene	Chr15:90113075-90173087 (-)
BALB/cJ	MGP_BALBcJ_G0022207	protein coding gene	Chr15:87633971-87693227 (-)
C3H/HeJ	MGP_C3HHeJ_G0021977	protein coding gene	Chr15:90112592-90189211 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022652	protein coding gene	Chr15:94311312-94378266 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020177	protein coding gene	Chr15:83705908-83761176 (-)
CAST/EiJ	MGP_CASTEiJ_G0021499	protein coding gene	Chr15:90883676-90949239 (-)
CBA/J	MGP_CBAJ_G0021944	protein coding gene	Chr15:97522726-97587213 (-)
DBA/2J	MGP_DBA2J_G0022071	protein coding gene	Chr15:86968948-87027178 (-)
FVB/NJ	MGP_FVBNJ_G0022050	protein coding gene	Chr15:86034907-86092656 (-)
LP/J	MGP_LPJ_G0022142	protein coding gene	Chr15:91155857-91222581 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022070	protein coding gene	Chr15:101899575-101967693 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022667	protein coding gene	Chr15:90171576-90234706 (-)
PWK/PhJ	MGP_PWKPhJ_G0021240	protein coding gene	Chr15:87022648-87084494 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021074	protein coding gene	Chr15:89910744-89975112 (-)
WSB/EiJ	MGP_WSBEiJ_G0021548	protein coding gene	Chr15:90648921-90717741 (-)

Human Ortholog

SYT10, synaptotagmin 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SYT10, synaptotagmin 10
Links

HGNC:19266

NCBI Gene ID: 341359

neXtProt AC: NX_Q6XYQ8

UniProt: Q6XYQ8
Chr Location

12p11.1; chr12:33374238-33439819 (-) GRCh38

MGI Vertebrate Homology

Syt10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SYT10
Gene Tree

Syt10

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Syt10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available

Mice homozygous for a knock-in allele exhibit minor circadian rhythm impairments.

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All GO Annotations

30
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

99
cDNA Data

6
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

10
UniProt

2
CCDS

CCDS27756.1

Ensembl

ENSMUSG00000063260 (Evidence)
NCBI Gene

54526

			Length	Strain/Species	Flank
genomic	ENSMUSG00000063260	Ensembl Gene Model \| MGI Sequence Detail	59468	C57BL/6J	± kb
transcript	ENSMUST00000029441	Ensembl \| MGI Sequence Detail	1845	Not Applicable
polypeptide	ENSMUSP00000029441	Ensembl \| MGI Sequence Detail	523	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015895 synaptotagmin-10

(term hierarchy)
InterPro Domains

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR001565 Synaptotagmin

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All nucleic 8

cDNA 6

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 56

Developmental Gene Expression 3

Diseases 1

Gene Ontology 7

Phenotypes 33
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:357381 Mortimer T, et al., The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis. Cell Stem Cell. 2024 Apr 27;

TSS for Syt10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135921	Chr15:89726127-89726138 (-)	-70 bp
Tssr135920	Chr15:89726096-89726126 (-)	-48 bp
Tssr135919	Chr15:89726006-89726017 (-)	51 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24