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Nup210 Gene Detail
Summary
  • Symbol
    Nup210
  • Name
    nucleoporin 210
  • Synonyms
    gp190, gp210, Pom210
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859555
    NCBI Gene: 54563
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:90990050-91093811 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 40.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2631 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859555
 protein coding gene Chr6:90990049-91095920 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031042
 protein coding gene Chr6:92586558-92695364 (-)
A/J MGP_AJ_G0031010
 protein coding gene Chr6:89060139-89165180 (-)
AKR/J MGP_AKRJ_G0030942
 protein coding gene Chr6:91530453-91640081 (-)
BALB/cJ MGP_BALBcJ_G0031022
 protein coding gene Chr6:89001291-89105651 (-)
C3H/HeJ MGP_C3HHeJ_G0030686
 protein coding gene Chr6:92799280-92910108 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031481
 protein coding gene Chr6:95002589-95116167 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028649
 protein coding gene Chr6:87037098-87142838 (-)
CAST/EiJ MGP_CASTEiJ_G0030129
 protein coding gene Chr6:91646184-91755101 (-)
CBA/J MGP_CBAJ_G0030708
 protein coding gene Chr6:98531910-98646459 (-)
DBA/2J MGP_DBA2J_G0030861
 protein coding gene Chr6:88246416-88350527 (-)
FVB/NJ MGP_FVBNJ_G0030815
 protein coding gene Chr6:87453982-87556806 (-)
LP/J MGP_LPJ_G0030941
 protein coding gene Chr6:92544480-92654619 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030849
 protein coding gene Chr6:102612294-102721146 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031508
 protein coding gene Chr6:91373803-91484710 (-)
PWK/PhJ MGP_PWKPhJ_G0029845
 protein coding gene Chr6:87171299-87296446 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029674
 protein coding gene Chr6:90283150-90393641 (-)
WSB/EiJ MGP_WSBEiJ_G0030213
 protein coding gene Chr6:91833278-91941832 (-)



Homology
more
  • Human Ortholog
    NUP210, nucleoporin 210
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUP210, nucleoporin 210
  • Synonyms
    GP210, POM210
  • Links
    NCBI Gene ID: 23225
    neXtProt AC: NX_Q8TEM1
    UniProt: Q8TEM1

  • Chr Location
    3p25.1; chr3:13316235-13420322 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 6 alleles in 6 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased naive T cells and increased activated T cells due to impaired peripheral T cell development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    35
  • cDNA Data
    91
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030091 Ensembl Gene Model | MGI Sequence Detail 103762 C57BL/6J ±  kb
    transcript ENSMUST00000032179 Ensembl | MGI Sequence Detail 7037 Not Applicable  
    polypeptide ENSMUSP00000032179 Ensembl | MGI Sequence Detail 1886 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000011513 nuclear pore membrane glycoprotein 210
      (term hierarchy)
    • InterPro Domains
      IPR003343 Bacterial Ig-like domain, group 2
      IPR008964 Invasin/intimin cell-adhesion fragments
      IPR045197 Nuclear pore membrane glycoprotein 210-like
    • GlyGen
      Q9QY81 12 sites, 10 N-linked glycans (8 sites)
    Molecular
    Reagents
    less
    • All nucleic 98
      cDNA 93
      Primer pair 3
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141476
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:59628 Olsson M, et al., cDNA cloning and embryonic expression of mouse nuclear pore membrane glycoprotein 210 mRNA. Kidney Int. 1999 Sep;56(3):827-38
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory