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Gripap1 Gene Detail
Summary
  • Symbol
    Gripap1
  • Name
    GRIP1 associated protein 1
  • Synonyms
    DXImx47e, GRASP-1, Sfc10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859616
    NCBI Gene: 54645
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7656009-7686805 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.51 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    653 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859616
 protein coding gene ChrX:7656004-7686806 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035524
 protein coding gene ChrX:2408554-2439645 (+)
A/J MGP_AJ_G0035502
 protein coding gene ChrX:2368463-2401296 (+)
AKR/J MGP_AKRJ_G0035434
 protein coding gene ChrX:2488446-2519411 (+)
BALB/cJ MGP_BALBcJ_G0035498
 protein coding gene ChrX:2392593-2427677 (+)
C3H/HeJ MGP_C3HHeJ_G0035206
 protein coding gene ChrX:2457275-2492769 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036022
 protein coding gene ChrX:2493016-2530242 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032898
 protein coding gene ChrX:1935057-1966486 (+)
CAST/EiJ MGP_CASTEiJ_G0034507
 protein coding gene ChrX:2349742-2379173 (+)
CBA/J MGP_CBAJ_G0035176
 protein coding gene ChrX:2614949-2645672 (+)
DBA/2J MGP_DBA2J_G0035333
 protein coding gene ChrX:2393837-2428394 (+)
FVB/NJ MGP_FVBNJ_G0035280
 protein coding gene ChrX:2357068-2388096 (+)
LP/J MGP_LPJ_G0035411
 protein coding gene ChrX:2428331-2461509 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035320
 protein coding gene ChrX:2587646-2619326 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036040
 protein coding gene ChrX:2394730-2428169 (+)
PWK/PhJ MGP_PWKPhJ_G0034208
 protein coding gene ChrX:2326328-2357619 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034046
 protein coding gene ChrX:2371639-2404827 (+)
WSB/EiJ MGP_WSBEiJ_G0034630
 protein coding gene ChrX:2403861-2435475 (+)



Homology
more
  • Human Ortholog
    GRIPAP1, GRIP1 associated protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIPAP1, GRIP1 associated protein 1
  • Synonyms
    GRASP-1
  • Links
    NCBI Gene ID: 56850
    neXtProt AC: NX_Q4V328
    UniProt: Q4V328

  • Chr Location
    Xp11.23; chrX:48973720-49002265 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects long term potentiation in hippocampal neurons resulting in impaired spatial and associative learning and memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    20
  • cDNA Data
    55
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54645 NCBI Gene Model | MGI Sequence Detail 30797 C57BL/6J ±  kb
transcript NM_001359289 RefSeq | MGI Sequence Detail 3604 C57BL/6  
polypeptide Q8VD04 UniProt | EBI | MGI Sequence Detail 806 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    Genomic 4
    cDNA 55
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2147934
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 3
  • Earliest
    J:62168 Means GD, et al., A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Genomics. 2000 May 1;65(3):213-23
  • Latest
    J:305154 Wilkinson B, et al., Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders. Biol Psychiatry. 2019 Feb 15;85(4):305-316
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory