Pdgfc MGI Mouse Gene Detail - MGI:1859631 - platelet-derived growth factor, C polypeptide

Symbol

Pdgfc
Name

platelet-derived growth factor, C polypeptide
Synonyms

1110064L01Rik, PDGF-C

Feature Type

protein coding gene
IDs

MGI:1859631
NCBI Gene: 54635
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:80943723-81121347 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 35.73 cM
Mapping Data

5 experiments

SNPs within 2kb

6007 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859631	protein coding gene	Chr3:80943723-81121347 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027321	protein coding gene	Chr3:80812413-81001150 (+)
A/J	MGP_AJ_G0027283	protein coding gene	Chr3:78132645-78319783 (+)
AKR/J	MGP_AKRJ_G0027251	protein coding gene	Chr3:79964408-80144547 (+)
BALB/cJ	MGP_BALBcJ_G0027294	protein coding gene	Chr3:78210501-78385421 (+)
C3H/HeJ	MGP_C3HHeJ_G0027038	protein coding gene	Chr3:80290700-80471738 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027740	protein coding gene	Chr3:83881368-84068214 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025093	protein coding gene	Chr3:73951897-74122010 (+)
CAST/EiJ	MGP_CASTEiJ_G0026485	protein coding gene	Chr3:80392681-80594374 (+)
CBA/J	MGP_CBAJ_G0027013	protein coding gene	Chr3:86673056-86868155 (+)
DBA/2J	MGP_DBA2J_G0027149	protein coding gene	Chr3:77690279-77866945 (+)
FVB/NJ	MGP_FVBNJ_G0027117	protein coding gene	Chr3:76010364-76182651 (+)
LP/J	MGP_LPJ_G0027257	protein coding gene	Chr3:81814785-81996882 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027136	protein coding gene	Chr3:92976985-93184205 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027798	protein coding gene	Chr3:79791241-79989995 (+)
PWK/PhJ	MGP_PWKPhJ_G0026219	protein coding gene	Chr3:77426972-77603840 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026035	protein coding gene	Chr3:78966549-79153683 (+)
WSB/EiJ	MGP_WSBEiJ_G0026563	protein coding gene	Chr3:80133020-80324537 (+)

Human Ortholog

PDGFC, platelet derived growth factor C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDGFC, platelet derived growth factor C
Synonyms

FALLOTEIN, SCDGF
Links

HGNC:8801

NCBI Gene ID: 56034

neXtProt AC: NX_Q9NRA1

UniProt: Q9NRA1
Chr Location

4q32.1; chr4:156760454-156971799 (-) GRCh38

MGI Vertebrate Homology

Pdgfc stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDGFC
Gene Tree

Pdgfc

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References

1 with disease annotations

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Phenotype Summary

28 phenotypes from 5 alleles in 6 genetic backgrounds
23 phenotypes from multigenic genotypes
1 images
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

10
Radiation induced

1
Targeted

10
Genomic Mutations

2 involving Pdgfc
Incidental Mutations

APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutation of this gene results neonatal and postnatal lethality with cleft palate, hypoplastic palatine bones, edema, blistering, and a short nasal septum with one allele or abnormal retinal pigmentation with a second allele.

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All GO Annotations

38
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1250
Tissues

207
cDNA Data

17
Literature Summary

36

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PDGFC

Xenbase pdgfc

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All Sequences

49
RefSeq

4
UniProt

2
CCDS

CCDS17425.1

Ensembl

ENSMUSG00000028019 (Evidence)
NCBI Gene

54635

			Length	Strain/Species	Flank
genomic	54635	NCBI Gene Model \| MGI Sequence Detail	177625	C57BL/6J	± kb
transcript	NM_001357746	RefSeq \| MGI Sequence Detail	3596	C57BL/6
polypeptide	Q8CI19	UniProt \| EBI \| MGI Sequence Detail	345	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000000703 platelet-derived growth factor C

(term hierarchy)
InterPro Domains

IPR000859 CUB domain

IPR029034 Cystine-knot cytokine

IPR000072 PDGF/VEGF domain

IPR035914 Spermadhesin, CUB domain superfamily
GlyGen

Q8CI19 3 sites, 2 N-linked glycans (2 sites)

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All nucleic 21

cDNA 17

Primer pair 1

Other 3

Microarray probesets 4

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MGI:1916128, MGI:2139772

Summaries

All 106

Developmental Gene Expression 36

Diseases 1

Gene Ontology 13

Phenotypes 37
Earliest

J:62052 Li X, et al., PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor [see comments]. Nat Cell Biol. 2000 May;2(5):302-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pdgfc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29617	Chr3:80943667-80943678 (+)	-50 bp
Tssr29618	Chr3:80943945-80944045 (+)	272 bp
Tssr29619	Chr3:80944272-80944318 (+)	572 bp
Tssr29620	Chr3:80944372-80944383 (+)	655 bp
Tssr29621	Chr3:80944444-80944512 (+)	755 bp
Tssr29622	Chr3:80944519-80944532 (+)	803 bp
Tssr29623	Chr3:80944686-80944698 (+)	969 bp
Tssr29624	Chr3:81116300-81116308 (+)	172,581 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24