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Usp27x Gene Detail
Summary
  • Symbol
    Usp27x
  • Name
    ubiquitin specific peptidase 27, X chromosome
  • Synonyms
    Sfc11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859645
    NCBI Gene: 54651
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:7238830-7242069 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859645
 protein coding gene ChrX:7237513-7242069 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035510
 protein coding gene ChrX:1968874-1973423 (-)
A/J MGP_AJ_G0035488
 protein coding gene ChrX:1942584-1947348 (-)
AKR/J MGP_AKRJ_G0035421
 protein coding gene ChrX:2025484-2030018 (-)
BALB/cJ MGP_BALBcJ_G0035484
 protein coding gene ChrX:1963248-1967791 (-)
C3H/HeJ MGP_C3HHeJ_G0035192
 protein coding gene ChrX:2014825-2019371 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036008
 protein coding gene ChrX:2043361-2050203 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032883
 protein coding gene ChrX:1512018-1516508 (-)
CAST/EiJ MGP_CASTEiJ_G0034492
 protein coding gene ChrX:1910028-1914581 (-)
CBA/J MGP_CBAJ_G0035162
 protein coding gene ChrX:2146303-2150846 (-)
DBA/2J MGP_DBA2J_G0035319
 protein coding gene ChrX:1964977-1969518 (-)
FVB/NJ MGP_FVBNJ_G0035266
 protein coding gene ChrX:1930271-1934600 (-)
LP/J MGP_LPJ_G0035396
 protein coding gene ChrX:1974624-1979168 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035305
 protein coding gene ChrX:2125941-2130479 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036026
 protein coding gene ChrX:1963786-1968341 (-)
PWK/PhJ MGP_PWKPhJ_G0034194
 protein coding gene ChrX:1892987-1897506 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034031
 protein coding gene ChrX:1917925-1922444 (-)
WSB/EiJ MGP_WSBEiJ_G0034615
 protein coding gene ChrX:1964979-1969590 (-)



Homology
more
  • Human Ortholog
    USP27X, ubiquitin specific peptidase 27 X-linked
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP27X, ubiquitin specific peptidase 27 X-linked
  • Synonyms
    MRX105, USP22L, USP27, XLID105
  • Links
    NCBI Gene ID: 389856
    neXtProt AC: NX_A6NNY8
    UniProt: A6NNY8

  • Chr Location
    Xp11.23
Human Diseases
more
  • Diseases
    1 with human USP27X associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    29
  • cDNA Data
    6
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54651 NCBI Gene Model | MGI Sequence Detail 3240 C57BL/6J ±  kb
transcript NM_019461 RefSeq | MGI Sequence Detail 3240 ZRU/MplStud  
polypeptide Q8CEG8 UniProt | EBI | MGI Sequence Detail 438 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    Genomic 1
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 21
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:62168 Means GD, et al., A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Genomics. 2000 May 1;65(3):213-23
  • Latest
    J:235307 Weber A, et al., The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. EMBO Rep. 2016 May;17(5):724-38
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory